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关键词： Computer-Aided Design   Recommendation system   Deep learning   Sentence embedding   Sequential pattern recognition   Geometric modeling  

摘要： *** CAD command prediction has progressed significantly,shifting from traditional statistical techniques to more advanced deep learning *** approaches—such as frequency-based methods(Myers,1998),first-order Markov models(Company et al.,2005),and their higher-order extensions(Rabiner,1989)—offered foundational insights but fell short in capturing semantic relationships and modeling complex dependencies.

关键词： 参数化建模   自动化设计   机械零件   CAD  

摘要： 随着机械制造业向智能化、数字化转型,零件设计的自动化水平亟待提升。本文从参数化建模的理论基础出发,深入探讨了机械零件几何特征的参数化表达方法、设计参数的分类优化策略以及模板构建技术。通过建立工程计算与参数映射模块、基于规则的设计逻辑和API驱动的自动化建模流程,实现了从设计需求到最终模型的全流程自动化。研究成果为提升设计效率、保证产品质量提供了有效的技术路径。

关键词： angiogenesis   coronary artery disease   DPP-4 inhibition   linagliptin   sex disparities   ANOVA   analysis of variance   CAD   coronary artery disease   CO   cardiac output   DDP-4   dipeptidyl peptidase-4   GLP-1   glucagon-like peptide 1   IHD   ischemic heart disease   LCx   left circumflex coronary artery   LDHA   lactate dehydrogenase A   PKM1/2   pyruvate kinase M1/M2   SGLT-2   sodium-glucose cotransporter 2   SV   stroke volume   SW   stroke work  

摘要： There are striking sex disparities among cardiometabolic disorders; however, the understanding of its underlying disease pathology remains uncertain, creating insufficient preventative and therapeutic approaches. Our study investigates the sex-specific response to the dipeptidyl peptidase-4 inhibitor, linagliptin in a clinically meaningful model of metabolic syndrome and chronic myocardial ischemia.

关键词： CAD   命令流   增量传输   日志模型   双层存储  

摘要： 为实现云端CAD文件的快速存储,提出一种基于命令流的云端CAD文件存储方法。构建命令流数据存储模型,将客户端操作命令分类表示为命令流,并以键值对的形式进行增量传输存储;构建命令流日志模型,以命令作为最小事务单元,将用户建模操作表示为可记录、可重放和可验证的操作日志序列,实现命令流原子性写入、命令重放、版本追踪与状态恢复。同时,搭建云端CAD文件存储架构,包括交互模块、命令流处理模块和数据存储模块,采用双层存储模式分别存储命令流、几何和拓扑数据。经实例测试,表明该方法能够快速且准确对云端三维CAD文件进行传输,验证了该方法的有效性。

关键词： coronary artery disease   multimodal feature fusion   noninvasive   retinal imaging   AUC   area under the receiver operating characteristic curve   CAD   coronary artery disease   CAG   coronary angiography   CVD   cardiovascular diseases   ECG   electrocardiogram   NPV   negative predictive value   OCT   optical coherence tomography   OCTA   optical coherence tomography angiography   PPV   positive predictive value   ROC   receiver operating characteristic  

摘要： Coronary artery disease (CAD) is a leading cause of morbidity and mortality globally. However, current detection methods have various safety concerns and are not suitable for all populations. Exploring safe, noninvasive detection methods is crucial.

关键词： CAD modeling   CFD   Footwear   Heat transfer  

摘要： This study addresses the challenge of evaluating the thermal insulation of technical footwear designed for cold environments. The aim is to develop a calculation tool to predict the thermal resistance (R${}_{cT}$, in m${}^2$K/W) of new footwear models before prototypes are manufactured. The model assumes stationary heat transfer and solves the relevant energy balance equations using a finite volume approach that takes into account the heterogeneous thermal properties of footwear components. Two simulation campaigns were carried out. In the first, tests with human subjects were simulated, where the boundary conditions included a prescribed internal heat flux (60 W/m${}^2$), a fixed ground contact temperature (-17 °C), and convective heat transfer to the outer surface. The second set of simulations mimicked manikin tests (UNI EN ISO 15831:2004), using fixed temperatures at the foot–shoe interface and on the floor (10 °C) and external convection. Validation with experimental data showed good agreement, underpinning the model’s ability to assess insulation performance under controlled conditions. Further simulations investigated the effects of different environmental parameters (temperature, wind speed, and ground contact) on heat loss. Statistical analysis revealed that ambient temperature had the greatest influence, explaining 37% of the total variance in heat flux, followed by ground type (22%) and wind speed (13%). This tool not only enables early assessment of thermal insulation in unbuilt prototypes, reducing reliance on time-consuming laboratory testing, but also supports detailed therma

关键词： 高科技纺织品   个性化定制   智能家纺   制造服务化  

摘要： 高科技纺织技术与定制化服务的深度融合正在重塑家纺产业竞争格局。文章从理论层面解析了高科技家纺的技术矩阵与功能延展性,解构了个性化定制范式的运行逻辑与价值锚点,并论证了二者互为增强的创新耦合机制。基于这一框架,本文系统阐述了该融合模式落地的核心路径,包括用户需求导向的功能美学集成设计、覆盖全流程的数字制造技术链,以及支持敏捷响应的柔性家纺供应网络。这种融合不仅推动产品形态革新,更引发产业根本性跃迁,具体表现为制造服务化模式转型、以用户体验为核心的价值网络重组,以及跨主体协同的创新生态系统构建。

关键词： 纺织品   壳聚糖   高效液相色谱法   氨基葡萄糖  

摘要： 本文建立了纺织品中壳聚糖含量的高效液相色谱测定方法。样品经水解和衍生后,衍生溶液采用Eclipse Plus C18色谱柱分离,乙腈-0.05 mol/L磷酸二氢钾缓冲溶液作为流动相进行洗脱,二极管阵列检测器进行分析,外标法定量。结果表明,壳聚糖的线性关系大于0.99,检出限和定量限分别为15 mg/kg和50 mg/kg,平均加标回收率范围为85.4%~102.3%,相对标准偏差为3.1%~9.3%。方法的专属性强,可用于纺织品中壳聚糖含量的测定。

关键词： 伏格列波糖   含量测定   有关物质   高效液相色谱   电雾式检测器   亲水相互作用色谱   质量控制  

摘要： 建立了基于亲水相互作用色谱模式的HPLC-电雾式检测器(CAD)法,用于测定伏格列波糖原料药的有关物质和含量。采用Agilent InfinityLab Poroshell 120 HILIC-Z色谱柱(3.0 mm×150 mm,2.7μm),以200 mmol/L甲酸铵溶液(用甲酸调至pH 3.0)和乙腈(体积比250∶750)为流动相,流速为0.5 mL/min,柱温为50℃,CAD温度50℃,数据采集频率2 Hz,过滤常数为3.6 s。方法学研究结果显示,主峰及各杂质间分离度良好,且在相应的质量浓度范围内具有良好的线性关系。3个已知杂质的平均加样回收率(n=9)分别为103.0%、99.0%、95.6%,RSD分别为4.1%、5.6%、4.2%,主成分的平均回收率(n=9)为100.0%,RSD为1.1%;伏格列波糖及其杂质Ⅰ、Ⅱ、Ⅲ的检测限分别为1.3、2.6、3.3、1.5 ng。该法操作简单、专属性强,可为无紫外吸收的强极性化合物的质量控制研究提供参考。

关键词： 紫外检测器与电雾式检测器串联的高效液相色谱法   复方氨酚烷胺片   含量测定   对乙酰氨基酚   盐酸金刚烷胺   咖啡因   马来酸氯苯那敏  

摘要： 目的:建立一种同时测定复方氨酚烷胺片中对乙酰氨基酚、盐酸金刚烷胺、咖啡因和马来酸氯苯那敏4种组分含量的方法。方法:采用UV检测器和CAD检测器串联的高效液相色谱法。色谱柱为phenomenex Kinetex XB-C18100Å(4.6 mm×150 mm,3.5μm),流动相为水(含0.1%三氟醋酸)-乙腈(梯度洗脱),流速为1.0 mL·min^(-1),柱温25℃,检测波长为273 nm,待对乙酰氨基酚和咖啡因出峰结束后切换至264 nm检测马来酸氯苯那敏,盐酸金刚烷胺采用CAD检测器,采集频率为5 Hz,过滤常数为3.6 s,雾化温度为50℃。结果:4种组分在考察的质量浓度范围内呈良好的线性关系(r>0.999);精密度、稳定性、重复性试验的RSD<2.0%;平均加样回收率为99.3%~100.8%(RSD为0.6%~1.4%,n=9)。结论:该方法操作简便,精密度、稳定性、重复性好,可用于同时测定复方氨酚烷胺片中4种组分含量。