课程文献中心 更多>>

关键词： FND   integrative medicine   CIM   CAM  

摘要： There is growing evidence supporting specific approaches to treat functional neurological disorder (FND), which commonly employ a multidisciplinary strategy guided by the biopsychosocial model and holistic perspective. Integrative Medicine and Health is an emerging specialty that brings together conventional and complementary modalities to deliver coordinated and comprehensive care. Although integrative approaches can be incorporated into existing care models, their application in the treatment of FND has not been systematically investigated, and programs employing such approaches to FND remain exceedingly rare. This study outlines the potential role of integrative care in FND. It will characterize the integrative approach and highlight its potential benefits for FND, review current evidence for relevant therapies, propose a potential clinic workflow, and illustrate its application through clinical case vignettes.

关键词： Disassembly sequence optimization   Quantum computing   Robotic automation   CAD integrated system  

摘要： Disassembly is the core of sustainable recovery processes, enabling the reuse, remanufacturing, and recycling of end-of-life products. Disassembly Sequence Optimization (DSO) is the key to achieving practical and efficient disassembly applications in industrial scenarios. This study presents a novel approach to DSO by leveraging Quantum Annealing (QA) through Quadratic Unconstrained Binary Optimization (QUBO) and Constrained Quadratic Model (CQM) formulations integrated with CAD-based assembly designs. The proposed methods aim to address computational challenges in industrial disassembly applications. We evaluated these methods against classical heuristics using two distinct product designs. For a smaller, denser assembly, the hybrid CQM model demonstrated superior performance in terms of solution quality and computational time. Conversely, for a larger, sparser assembly, a classical heuristic achieved better results in solution quality when constraining computational time compared to the hybrid quantum approaches. The QUBO model, although did not overcome classical, showed promise in exploring solution spaces, obtaining better solution quality than CQM for the larger problem. These findings indicate that the current practical utility of quantum annealing for DSO is influenced by problem size, structure, and hybrid workflow efficiency. Future research should focus on optimizing the balance between classical and quantum resources to further enhance efficiency. As quantum hardware continues to advance, these formulations have the potential to revolutionize sustainable manufacturing by optimizing disassembly planning with greater efficiency and adaptability to large assemblies.

关键词： biaxial flexural strength   CAD/CAM ceramics   esthetic dentistry   lithium disilicate ceramics   scanning electron microscopy  

摘要： Objective: This study aimed to assess and compare the biaxial flexural strength (BFS) and microstructure of lithium-based CAD/CAM ceramics. Material and Methods: Eighty disc-shaped specimens were fabricated from four distinct Lithium-containing CAD/CAM ceramic blocks. Twenty samples were allocated to each category: IPS *** CAD, GC LiSi Block, CEREC Tessera, and an unbranded ceramic. Universal testing machine equipment facilitated BFS testing in compliance with ISO 6872:2015 standards. Scanning electron microscopy (SEM) alongside energy-dispersive spectroscopy (EDS) techniques were employed for analysis of microstructural properties. One-way ANOVA followed by Tukey's post hoc test comprised the statistical evaluation, with a significance level of alpha = 0.05. Calculations of the Weibull modulus (m) and characteristic strength (sigma(0)) determined material reliability. Results: CEREC Tessera showed the highest mean biaxial flexure strength and characteristic strength (biaxial flexure strength: 580.6 +/- 208, sigma(0) = 659 MPa). GC LiSi Block showed the lowest values (biaxial flexure strength: 351 +/- 71 MPa, sigma(0) = 381 MPa). Statistically significant differences appeared between GC LiSi Block and the other groups (p < 0.05). No differences appeared among IPS *** CAD, CEREC Tessera, and the unbranded ceramic (p > 0.05). SEM analysis revealed rod-like lithium disilicate crystals in IPS *** CAD and the unbranded material, whereas CEREC Tessera and GC LiSi Block exhibited spherical crystals, indicating substantial microstructural variation. Zirconia peaks appeared only in IPS *** CAD. Conclusions: Differences in biaxial flexure strength and microstructure appeared among the tested ceramics. GC LiSi Block showed the lowest mechanical performance. IPS *** CAD, CEREC Tessera, and the unbranded material showed similar values. Both research hypotheses gained support.

关键词： Model coordination   Building Information Modeling (BIM)   Immersive technology   3D Gaussian Splatting (3D GS)   Multi-dimensional coordination   ISO 19650 standard   Life cycle  

摘要： Traditional construction project management approaches suffer from technical isolation and process deficiencies, particularly in whole-life-cycle model coordination. This paper addresses how to develop a comprehensive management framework that optimizes model coordination through technology integration. This multi-technology integration framework combines CAD drawings, Building Information Modeling (BIM), immersive technology, and 3D Gaussian Splatting scanning while implementing ISO 19650 standards for information management. A hospital project case study was used and validated featuring complex structural and mechanical, electrical, and plumbing (MEP) coordination scenarios. This empirical study demonstrated an approximate 22%-35% reduction in pipeline dismantling rates, 40% shorter review cycles for complex nodes, and significantly improved construction quality verification accuracy. These outcomes highlight how technological synergies can overcome traditional management limitations and establish a robust foundation for future engineering projects. Future research should validate the framework across diverse project types, explore additional integrated technologies, and conduct long-term impact assessments during operation phases.

关键词： CAD   MI   Non-adherence   Preventive cardiology   Re-MI   Secondary prevention  

摘要： Background Recurrent myocardial infarction (re-MI) remains a significant challenge in cardiovascular care, especially in low-income countries. Despite advancements in cardiac care, many patients with coronary artery disease (CAD) fail to follow the secondary prevention guidelines consistently. This study aims to determine the independent predictors of re-MI and inadequate adherence to secondary prevention strategies among adults with CAD in a rural cohort in South India. Methods A nested case-control study with risk set sampling of controls was conducted from January 2022 to March 2022 within the ENDIRA (Epidemiology of Non-communicable Diseases In Rural Areas) Cohort in the rural part of Aluva municipality of Ernakulam district, Kerala, India. CAD patients aged 35-80 years from the ENDIRA cohort who have had one or more episodes of myocardial infarction 28 days post the index episode as confirmed by medical reports were selected as cases while those with no recurrent episodes were taken as controls. Descriptive analysis was conducted to characterise the study population and was expressed in frequencies and percentages. Regression models were used to determine the independent predictors of re-MI as well as inadequate adherence and was expressed using adjusted odds ratio along with 95% confidence intervals. Results The study included 187 cases and 436 controls. The independent predictors of recurrent myocardial infarction included poor socio-economic status (Adjusted Odds Ratio [AOR] 1.98;95% confidence interval [CI] 1.34-2.91), > 5 years since CAD diagnosis (AOR 1.53;95% CI 1.06-2.22), previous history of CABG (AOR 1.75;95% CI 1.17-2.61), alcohol consumption (AOR 1.65;95% CI 1.04-2.61), follow up under complementary and alternative medicine (AOR 2.04;95% CI 1.03-4.01), distance to follow up hospital > 20 kms (AOR 1.85;95% CI 1.09-3.12) and uncontrolled blood pressure (AOR 1.60;95% CI 1.07-2.39). The CAD patients preferring private facilities for follow up were 43% l

关键词： CAM/CML gene family   Cremastra appendiculata   Mycorrhizal fungi  

摘要： Background Calmodulin (CAMs) and calmodulin-like proteins (CMLs) play pivotal roles in sensing and decoding Ca2+ signals, thereby regulating of various physiological processes. Although CAM/CML genes in numerous plants have been extensively studied, their specific functions and mechanisms in orchids remain unexplored. In order to reveal the characteristics of the CAM/CML family in Cremastra appendiculata, a comprehensive analysis was performed at the genome-wide level, focusing on its physicochemical attributes, phylogenetic associations, gene structure, Cis-acting elements, and qRT-PCR. Results A total of 78 CAM/CML genes were identified in C. appendiculata, including five CAPPCAM and 73 CAPPCML, divided into ten subgroups (Subgroup I-X). Subgroups I and II contain one to four coding DNA sequences (CDS), while subgroup IX includes 9 genes with only one CDS and the remaining genes possess 4-12 CDS. The collinearity analysis revealed seven collinear CAM/CML gene pairs between C. appendiculata and Arabidopsis thaliana, indicating the homology of CAM/CML genes between these two species. The cis-elements in the CAPPCAMs/CMLs promoter mainly enrich methyl jasmonate (MeJA) elements (202/1120, 18%). The qRT-PCR analysis revealed that the CAPPCAM/CAPPCML gene family plays important roles in responding to mycorrhizal symbiosis. Notably, root tissues demonstrated a marked induction effect upon symbiosis, with gene expression regulation exhibiting distinct tissue specificity. Conclusions This study not only lays the foundation for clarifying the functions of such genes in mycorrhizal symbiosis of C. appendiculata, but also highlights its potential for biotechnology development.

关键词： CAD/CAM block   resin-based composite   SFRC   fracture toughness   polishability  

摘要： The existing scientific literature indicates that flowable short fiber-reinforced composites (SFRCs) can be used for direct restoration due to their favorable mechanical properties. However, there is a lack of data on the mechanical properties of SFRCs designed specifically for indirect CAD/CAM restorations. This study aims to fabricate a novel experimental SFRC CAD/CAM block and evaluate its fracture toughness and polishability as an indirect restoration in comparison with different conventional resin-based CAD/CAM blocks with different compositions. Fourier-transform infrared spectroscopy (FTIR) was employed to analyze the chemical structure of the Experimental SFRC group, while the microstructure of specimens from each group was examined using scanning electron microscopy (SEM). Then, this study divided the specimens into three groups-Group 1 (Grandio blocks), Group 2 (Cerasmart 270), and Group 3 (Experimental SFRC)-with 30 specimens in each group. Each group was then subdivided into sub-groups for the fracture toughness test, which evaluated resistance to crack propagation, and the surface roughness test, which assessed surface topography. FTIR analysis showed that the experimental SFRC exhibited distinct spectral changes after polymerization, confirming successful chemical reactions and network formation. SEM analysis showed that the Experimental SFRC block had a polymeric matrix with randomly oriented, well-dispersed short fibers. Grandio blocs exhibited a dense nanohybrid structure with irregular fillers, while Cerasmart 270 displayed a more uniform microstructure with evenly dispersed nano-sized spherical fillers. The Experimental SFRC showed the highest fracture toughness (2.758 MParoot m), surpassing the other groups (p < 0.05) and highlighting its superior resistance to crack propagation. Regarding surface roughness Ra, the novel Experimental SFRC group (0.182) presented a significant difference compared to other groups (p < 0.05) but within c

关键词： Photolysis  

摘要： Halogen bonding has emerged as a powerful yet underexplored tool for modulating radical reactivity. Here we demonstrate that halogen-bonding interactions between alkyl iodides and water can lower the C–I bond dissociation energy, enabling visible-light-induced photolysis to generate alkyl radicals under mild conditions. Harnessing this activation mode, we achieved a previously unknown 1,3-carbohydroxylation of allyl carboxylates, wherein radical addition is coupled with 1,2-cationic acyloxy migration (CAM) to furnish β-acyloxy alcohols. The transformation exhibits broad structural tolerance, accommodating diverse esters, thioesters, amides, and perfluoroalkyl iodides, and is effective in the late-stage diversification of natural products and drug-derived scaffolds. Mechanistic studies, including isotopic labeling, radical trapping, UV-vis spectroscopy, and DFT calculations, reveal a pathway in which halogen bonding initiates radical alkene addition, followed by rearrangement and carbocation capture. These findings showcase halogen-bonding-assisted photochemistry as a viable platform for radical–cationic cascades, opening new opportunities for reaction development.

关键词： Computer Aided Design (CAD)   Field Programmable Gate Array   Packing   Placement   Routing   Verilog To Routing (VTR)  

摘要： This is a corrigendum for the article “VTR 9: Open-Source CAD for Fabric and Beyond FPGA Architecture Exploration” published in ACM Trans. Reconfig. Technol. Syst. 18, 3, Article 39 (August 2025), 53 pages.