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关键词： 相变调温材料   微胶囊   智能调温纺织品   智能调温纤维   后整理  

摘要： 文章首先介绍了固-液相变调温材料的调温原理和性能测试方法,然后根据近些年相变调温微胶囊在智能调温纤维和纺织品中的应用,概述了相变调温微胶囊的研究现状和发展趋势,以期为相变微胶囊在纺织领域的应用扩展提供参考。

关键词： C1s inhibitor   cold agglutinin disease   long-term follow-up   sutimlimab  

摘要： Cold agglutinin disease (CAD) is a low-grade lymphoproliferative disorder accounting for 15%-30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM-kappa class that cause agglutination of red blood cells (RBCs) at temperatures <= 37 degrees C and activate the classical complement pathway with subsequent RBC destruction. Before the approval of the monoclonal antibody sutimlimab, treatment options were limited. Sutimlimab inhibits the classical complement pathway at C1s while sparing the lectin and alternative complement pathways. Efficacy, safety and tolerability of sutimlimab have been established in the multicenter CARDINAL and CADENZA trials. In the present investigation, 10 patients on sutimlimab were followed up to 96 weeks in the Managed Access Program (MAP) in Essen. Eight of these patients had previously participated in the multicenter trials and were restarted on sutimlimab after a median washout period of 12.6 weeks. In addition, two sutimlimab-naive patients were included. Hemoglobin concentration increased in all patients (median hemoglobin concentration before therapy 9.8 vs. 12.5 g/dL at the end of the study). Bilirubin levels normalized already after 2 weeks in all patients. Reticulocyte count declined in nine, haptoglobin and hemopexin concentrations normalized in six and 10 patients, respectively. In conclusion, the present investigation with primary CAD patients in a single center demonstrates long-term normalization of laboratory parameters, abrogation of specific clinical symptoms and absence of drug-related side effects with sutimlimab.

关键词： CRISPR Cas9   hormone   metamorphosis   RTK   silkworm  

摘要： Moulting and metamorphosis are fundamental physiological processes in the growth and development of holometabolous insects, primarily regulated by ecdysteroids and juvenile hormone (JH), which are synthesized and secreted by the prothoracic gland and corpora allata, respectively. However, the signalling regulatory network involved in the synthesis of these hormones and their effects is complex and interactive and involves many unidentified functional genes. In this study, we conducted a basic bioinformatics analysis of the CAD96CA gene and obtained CAD96CA mutants at the individual level in domestic silkworms using the CRISPR-Cas9 technology. We analysed the growth, development and silk protein synthesis phenotypes of the mutants and detected the synthesis and signalling effects of 20E and JH. The results revealed that knocking out the CAD96CA gene resulted in inhibited larval growth, reduced silk protein production, hindered larval-pupal transition and led to larval mortality. The synthesis of 20E and its signalling pathways, as well as the signalling pathways of JH, were all affected to varying degrees following CAD96CA knockout. Our study elucidates the role of CAD96CA in the growth and development of silkworms and provides a reference for studying metamorphosis mechanisms.

关键词： coronary artery disease   testosterone   Mendelian randomization   survival analysis   testosterone supplementation  

摘要： Context Testosterone supplementation is increasingly widespread and has well-established beneficial effects on sexual function and metabolic health. However, there remains uncertainty regarding associated cardiovascular *** Human genetics studies demonstrated that Mendelian randomization approaches recapitulate the beneficial effects of testosterone therapy;here we apply this to cardiovascular *** We performed a Mendelian randomization study to assess the causal effect of higher circulating testosterone on coronary artery disease (CAD). We also tested the phenotypic association between measured circulating testosterone and CAD in the cohort of men aged 40 to *** or Other Participants Testosterone genetic instrument data were derived from 425 097 European ancestry adults from the UK Biobank study and CAD from single nucleotide polymorphism-level summary statistics from 1 165 690 individuals in *** Outcome Measure(s) CAD as defined in CARDIoGRAMplusC4D was the main outcome. In longitudinal analyses, CAD was defined according to medical records and *** We found that higher genetically predicted circulating testosterone conferred a higher risk of CAD in men [odds ratio (OR): 1.17, 95% confidence interval (CI) 1.07-1.27, P = 3.32 x 10-4]. There was no evidence of an effect in women (OR: 1.01, 95% CI 0.94-1.10, P = .73). The genetic association in men appeared to be mediated by higher blood pressure. In longitudinal observational analyses, a directionally opposite association was observed in men, likely arising due to confounding by type 2 diabetes and body mass *** These data suggest that increased testosterone may increase the risk of cardiovascular disease and that this safety concern should be a focus in future clinical trials for testosterone supplementation.

关键词： Hepato-pancreato-biliary surgery   Intraoperative navigation   Three-dimensional imaging   Computer-aided design   CAD   Surgical education   Anatomical visualization   Robotic surgery   Robotic pancreatectomy  

摘要： Background In hepato-pancreato-biliary (HPB) surgery, precise anatomic understanding is *** Hepatobiliary Pancreat Surg. 23:145-154;2.J Hepatobiliary Pancreat Sci. 30:851-862;In Japan, advanced HPB board certification requires preoperative schema drawing.3.J Hepatobiliary Pancreat Sci. 24:252-261 Although three-dimensional (3D) imaging improves preoperative recognition,*** Gastroenterol Surg. 6:190-196;*** Surg Oncol. 32:3539-3543;*** Surg Oncol. 31:6567-6568;no widely adopted system exists for real-time intraoperative *** Surg. 271:e4-e7;*** J Comput Assist Radiol Surg. 20:117-129;*** Res Pract. 2021:9621323;At the authors' institution, schematic diagrams have been used, but they are time-consuming and limited in detail. To overcome these limitations, the authors developed a simple, low-cost intraoperative 3D navigation method using free computer-aided design (CAD) applications. Methods The authors analyzed 32 HPB cases managed between January and August 2025. Computed tomography (CT) data were reconstructed into 3D images using REVORAS (Ziosoft Inc., Tokyo, Japan). Based on these images, schematic diagrams were created with Procreate (Savage Interactive Pty Ltd., Australia), and CAD models were generated with Fusion 360 (Autodesk Inc., San Francisco, CA, USA) and Shapr3D (Shapr3D Zrt., Budapest, Hungary). The creation times were measured and compared. Results Surgical approaches included open (n = 14), robotic (n = 16), and laparoscopic (n = 2) procedures comprising pancreatic (n = 18), hepatic (n = 13), and sarcoma (n = 1) resection. Both schematic diagrams and CAD models were created in all cases. The median creation time was significantly shorter for CAD models (7 min 25 s) than for diagrams (19 min 48 s) (p < 0.01). The CAD models enabled real-time anatomic sharing via tablets with TilePro integration in the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA, USA). Conclusions Intraoperative CAD-based navig

关键词： 引纬机构   碰撞动力学   投梭压力角余弦耦合系数   多体动力学仿真   刚柔耦合  

摘要： 为了解决有梭织机引纬机构长期存在的高冲击、高磨损以及能量传递效率与冲击强度难以兼得的问题。文章基于经典撞击理论进行引纬机构动力学分析,并提出了一个核心设计参数——投梭压力角余弦耦合系数;进而,建立了以该系数为核心的引纬机构碰撞动力学模型,推导出撞击冲量、运动响应、有效冲击力及动能传递效率的显式表达式。最后,通过ADAMS平台构建了相应的刚柔耦合多体动力学仿真模型,对理论模型进行了多工况验证。结果表明,理论模型与仿真结果吻合良好;该系数的增大将单调加剧速度方向上的冲击载荷,并使动能传递效率单调下降,而该系数存在特定值使得运动响应速度获得最佳的动能输出。文章将传统依赖经验的参数调整转化为对该系数的调控与多目标权衡,可为引纬机构的优化设计提供理论工具与可行的工程路径。

关键词： 同轴静电纺丝   防护纺织品   智能响应   核壳结构   功能集成  

摘要： 随着防护需求从传统“被动防护”向“主动响应”升级,传统防护材料在复杂环境中的动态适应能力不足问题日益突出。同轴静电纺丝技术依托核壳结构设计,为智能响应型防护纺织品的构建提供了新的技术路径。围绕其成纤机理与结构形成机制,系统梳理核壳结构对力学增强、阻隔性能提升及功能组分稳定负载的调控规律;进一步总结不同材料体系在同轴静电纺丝技术中的研究进展;重点阐述其在防护纺织品中的应用。同时,展望了同轴静电纺丝技术在智能防护纺织品功能定制化方面的潜力,指出其在未来个性化防护与多功能集成领域的发展方向。研究可为同轴静电纺丝智能响应型防护纺织品的后续研究及产业化应用提供有益参考。