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关键词： Oxidative Stress   Nitric Oxide Signalling   Tetrahydrobiopterin (BH4)   Apoptosis Regulation   Breast Cancer Progression   BC   breast cancer   NOS   nitric oxide synthase   nNOS   neuronal nitric oxide synthase   iNOS   inducible nitric oxide synthase   eNOS   endothelial nitric oxide synthase   NO   nitric oxide   L-Cit   L-Citrulline   L-Arg   L-Arginine   NADPH   nicotinamide adenine dinucleotide phosphate   CaM   Calmodulin   ROS   reactive oxygen species   O 2   Superoxide   H 2O 2   hydrogen peroxide   OH   hydroxyl free radicle   COX   Cyclooxygenase   LOX   Lipoxygenase   DCIS   ductal carcinoma in situ   LCIS   lobular carcinoma in situ   IDC   invasive ductal carcinoma   ILC   invasive lobular carcinoma   EDRF   endothelial derived relaxing factor   NOX   NADPH oxidase   SOD   superoxide dismutase   ONOO   Peroxynitrate   CAT   catalase   GPX   glutathione peroxidase   PRX   peroxiredoxin   TRX   Thioredoxin   TR   thioredoxin reductase   GSH   glutathione   GSSG   glutathione disulfide   GR   glutathione reductase   LOO   lipoperoxyl radicle   LOOH   lipid hydroperoxides   GAPDH   Glyceraldehyde-3-phosphate dehydrogenase   SSB   single strand break   DSB   double strand break   JNK   c-Jun N-terminal Kinase   E   estrogen   ER   estrogen receptor   FMN   flavin mononucleotide   FAD   flavin adenine dinucleotide   BH4   Tetrahydrobipterin   BH2   dihydrobipterin   GTPCH   guanosine triphosphate cyclohydrolase   DHFR   dihydrofolate reductase   CAT   cationic amino acid transporter   DDAH   dimethylaminohydrolase  

摘要： Breast cancer (BC) remains a significant health problem globally, with complex underlying processes that are not fully understood. This study investigates the intricate relationship between endothelial nitric oxide synthase (eNOS) and reactive oxygen species (ROS) in the progressions of BC. Here we examine the essential roles of superoxide (O2·¯), hydrogen peroxide (H₂O₂), and hydroxyl free radicals (OH·) in promoting tumor development, angiogenesis, and metastasis. In addition, this review also analyzes the significant role of eNOS in BC, which highlighting its activation by estrogen and the impact of eNOS gene polymorphisms on cancer risk. Furthermore, we elucidate the mechanisms of eNOS uncoupling, primarily focusing on the deficiency of tetrahydrobiopterin (BH4), the depletion of L-Arginine (L-Arg), and the buildup of asymmetric dimethylarginine (ADMA). This extensive study provides novel insights into the molecular mechanisms connecting oxidative stress and NO signaling in BC. It identifies prospective targets for innovative treatment strategies. Hence, the outcomes of the study may highlight the importance of comprehending the complex balance between eNOS activity and ROS production in the progression of BC. This provides the foundation for further studies and targeted therapies in BC treatment.

关键词： 三维建模   相似检测   排列规律分析   AutoCAD   几何变换空间  

摘要： 针对人工完成建筑物二维CAD设计图纸转化为三维模型过程费时费力的问题,利用体育场馆中存在大量重复且规则排列物体的特点,提出一种相似图元检测算法,通过构建图元包围盒,并进行L2-Norm距离计算来检测图元间的相似性,检测CAD图纸中的所有同类型图元;提出一种变换序列检测算法,基于图元间的几何变换关系定义几何变换空间,通过在变换空间中进行聚类分析的方法来发现图元间的变换序列;基于分析排列规律自动计算图元的高度信息。仿真验证实验表明:所提方法可快速实现相似图元检测及排列规律分析,有效加速体育场馆的三维建模进程。

关键词： variable stiffness   mechanical model   permanent magnetic spring   flexible robot  

摘要： Variable-stiffness joints, with their inherent flexibility, enable highly secure human-robot interactions in unstructured environments. However, existing mechanisms are limited in terms of stiffness regulation flexibility and nonlinear centeracteristics. This paper proposes a compact variable-stiffness mechanism based on a nonlinear path surface coupled with a permanent magnetic nonlinear spring and a linear spring (LS), namely, permanent magnet-cam-variable stiffness actuators. This mechanism integrates the predictability of the LS, the rich magnetic-force nonlinearity of the permanent-magnet spring, and the nonlinear centeracteristics of the cam profile, thereby enabling arbitrary modulation of the stiffness curve. First, a mechanical model is established to examine how the cam-roller motion alters the LS deformation and the permanent-magnet air gap, thus revealing the mechanism of torque and stiffness modulation. Incorporating elastic deformation theory, the relationship between roller rotation angle, output torque, and equivalent stiffness is derived. Further simulation and experimental comparisons, performed by replacing different elastic elements, demonstrate that the proposed mechanism not only enables arbitrary adjustment of nonlinear stiffness but also exhibits superior torque range and response flexibility.

关键词： artificial intelligence   autoimmune   coronary artery calcium  

摘要： Corresponding Author

关键词： 三维织物   引纬机构   卷取机构   夹持机构   打纬机构  

摘要： 为解决大直径多层三维管状织物在织造过程中,连续引纬和卷取困难的问题,基于对剑杆织机的引纬机构和对圆筒织机卷取系统的研究,设计了一种应用于大直径多层三维管状织物引纬和卷取的一体化机构。该机构引纬利用异形钢筘作为引纬轨道,采用直线分段式引纬,借用气动滑轨机构引导钢筘进行打纬,完成锁纬。通过夹持块机构和滚珠丝杆机构,实现对织物的塑形和自动卷取。文章首先介绍了该机构的主要工作原理,针对各主要机构的设计和功能进行阐述,并通过有限元分析验证了引纬机构关键零部件的刚度和强度,最后对卷取机构进行受力分析和对压紧螺栓进行强度校核。该机构在实际织造过程中能够满足连续引纬和卷取的需求,同时引纬效率翻倍。

关键词： Automated inspection   CAM   Concrete crack   DenseCRF   Weakly supervised learning  

摘要： Cracks pose a major threat to the safety and durability of hydraulic concrete structures. However, existing crack segmentation methods often suffer from crack disconnection, blurred boundaries, over-segmentation in complex environments, and high annotation costs. To address these issues, this paper proposes a weakly supervised crack segmentation method—Dual-Stage Refined Class Activation Map with Ivy-optimized Dense Conditional Random Field (DSRCAM-ICRF)—which achieves high precision using only image-level labels. The framework consists of two stages. In Stage I RCAM, Convolutional Neural Network (CNN) and Transformer branches extract local and global features. In Stage II RCAM, attention weights from different layers are scaled and fused to account for depth-wise variation, enabling precise integration of hierarchical features and enhancing fine crack localization. The Ivy-optimized DenseCRF module further refines crack boundaries and mitigates over-segmentation. Experiments on UAV-captured datasets demonstrate superior performance, with a Mean Intersection over Union (MIoU) of 0.823, precision of 0.908, and F1-score of 0.901. This method offers a robust and scalable solution for automated crack detection in structural health monitoring.

关键词： Mucormycosis   FRS   CAM   Mucor  

摘要： To determine the relation between disease spectrum, etiology and immunological markers in fungal rhinosinusitis (FRS).

关键词： 革命文物   文保技术体系   纸质文献   纺织品  

摘要： 革命文物包括纸质文献、纺织品、金属器物等多种,材质不稳定且易被环境因素破坏,传统保护方法已无法满足复杂保存要求。随着X射线荧光光谱、数字孪生、物联网等技术在文物保护方面的深入应用,建立系统性、智能化的保护技术体系是革命纪念馆的必然做法。该体系不是单一技术的简单组合,而是通过技术整合形成“检测-监测-修复-传承”的完整流程,为革命文物提供全生命周期保护,保证红色文化遗产长久流传。

关键词： anthracycline   arterial stiffness   atherosclerosis   childhood cancer survivor   coronary artery disease   BMI   body mass index   BP   blood pressure   BSA   body surface area   CAD   coronary artery disease   CAYA   children, adolescents and young adults   CCS   childhood cancer survivors   cfPWV   carotid-femoral pulse wave velocity   cIMT   carotid intima-media thickness   DBP   diastolic blood pressure   EndoPAT   endothelial peripheral arterial tone test   FMD   flow-mediated dilation   HbA1c   hemoglobin A1c   HDLc   high-density lipoprotein concentration   IMT   intima-media thickness   LDLc   low-density lipoprotein concentration   LVEF   left ventricular ejection fraction   PWV   pulse wave velocity   SBP   systolic blood pressure  

摘要： Coronary artery disease is a major cause of late mortality among childhood cancer survivors (CCS), but the prevalence of early vascular changes remains poorly defined.

关键词： Boric acid   Calcium phosphate   CAM   Chitosan   Osteogenesis   Osteosarcoma  

摘要： Conventional bone tumour treatment often results in the disruption or collapse of the structural integrity of bone following tumour resection, while the accompanying application of chemotherapy frequently results in wide systemic damage due to toxicity. Such shortcomings in current bone tumour treatment options highlight the need for the development of multifunctional biomaterials that serve as systems for targeted drug delivery and biodegradable support, stimulating new bone formation. In this work, chitosan-calcium phosphate composite scaffolds were used as carriers for local delivery of antitumour drugs and therapeutic agents, while providing bioactive properties. The bioactivity of composite scaffolds was confirmed by an apatite-rich layer formation in an acellular in vitro test, and by osteogenic differentiation of human mesenchymal stem cells cultured for 21 days. The encapsulation of an antitumour drug, doxorubicin, was achieved through chemical crosslinking by genipin, while its release was characterised in a complete cell culture medium. The rapid release of doxorubicin affected the viability of human dermal fibroblasts (HDFa) and osteosarcoma cells (MG-63) when in contact with drug-loaded scaffolds. Following osteogenic properties, the modification of the composite scaffold with boric acid was also explored. The rapid release of boric acid from the composites was reported to be within the first three days of incubation, which stimulated a slight increase in the expression of vascular endothelial growth factor in HDFa cells. A biotolerability study was performed by chorioallantoic membrane (CAM) assay, indicating tissue infiltration into composite scaffolds with a lower concentration of boric acid. The rapid delivery of doxorubicin or boric acid from biodegradable and osteoconductive composite scaffolds shows the potential to address the clinical challenge of local tumour recurrence and poor bone regeneration following resection.