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关键词： ABH   2-(S)-amino-5-boronohexanic acid   ADMA   asymmetric dimethylarginine   Arg1   Arginase 1   Arg2   Arginase 2   CAD   coronary artery disease   CVD   cardiovascular disease   EC   endothelial cell   eNOS   endothelial nitric oxide synthase   GABR   global l-arginine bioavailability ratio   HSC   hepatic stellate cell   IL   interleukin   iNOS   inducible nitric oxide synthase   I/R   ischemia-reperfusion   ISPF   isonitrosopropiophenone   Km   Michaelis constant   MAPK   mitogen-activated protein kinase   MDSC   myeloid-derived suppressor cell   MI   myocardial infarction   MS   mass spectrometry   NO   nitric oxide   nor-NOHA   Nω-hydroxy-nor-arginine   NOS   nitric oxide synthase   RBC   red blood cell   PMN   polymorphonuclear neutrophil   SCD   sickle cell disease   SLC25A29   solute carrier family 25 member 29   STAT   signal transducer and activator of transcription   T2DM   type 2 diabetes mellitus   TCR   T cell receptor   Vmax   maximum reaction rate  

摘要： The enzyme arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea. The 2 existing isoforms Arg1 and Arg2 exhibit different cellular localizations and metabolic functions. Arginase activity is crucial for nitrogen detoxification in the urea cycle, synthesis of polyamines, and control of l-arginine bioavailability and nitric oxide (NO) production. Despite significant progress in the understanding of the biochemistry and function of arginases, several open questions remain. Recent studies have revealed that the regulation and function of Arg1 and Arg2 are cell type–specific, species-specific, and profoundly different in mice and humans. The main differences are in the distribution and function of Arg1 and Arg2 in immune and erythroid cells. Contrary to what was previously thought, Arg1 activity appears to be only partially related to vascular NO signaling under homeostatic conditions in the vascular wall, but its expression is increased under disease conditions and may be targeted by treatment with arginase inhibitors. Arg2 appears to be mainly a catabolic enzyme involved in the synthesis of l-ornithine, polyamine, and l-proline but may play a putative role in blood pressure control, at least in mice. The immunosuppressive role of arginase-mediated arginine depletion is a promising target for cancer treatment. This review critically revises and discusses the biochemistry, pharmacology, and in vivo function of arginases, focusing on the insights gained from the analysis of cell-specific Arg1 and Arg2 knockout mice and human studies using arginase inhibitors or pegylated recombinant arginase.

关键词： 工业设计   宋代   少儿题材   璎珞纹   纺织品  

摘要： 为探究宋代少儿题材璎珞纹的艺术魅力,并探究其在当代纺织品上的设计策略及实用价值,文章基于宋代少儿题材璎珞纹为研究对象,采用文献研究法和图像分析法,系统地梳理宋代少儿题材璎珞纹的发展渊源及特征,并对璎珞纹在当代纺织品中的设计应用现状进行分析,总结出璎珞纹在当代纺织品中“形”与“色”结合的设计策略,通过设计实践验证宋代少儿题材璎珞纹在当代纺织品设计中的可能性,使传统艺术转化为新的设计力量融入现代生活当中。

关键词： CAD模型   图卷积网络   加工特征识别   邻接矩阵  

摘要： 为解决CAD/CAPP/CAM集成过程中,三维CAD模型加工特征识别问题,提出了一种混合式图卷积网络(Hybrid spectral domain and spatial domain graph convolution networks, SSGCN)的特征识别算法。以三维模型的面为节点,边为节点间的连接关系,构建图数据结构。提取面的几何属性信息,自定义编码构建节点属性矩阵,作为网络的输入。提取图结构的邻接矩阵、度矩阵等构建混合式图卷积网络。通过Python-OCC相关算法以及布尔运算,设计了一种批量生成带有面标签的加工特征模型数据集算法。使用带有面标签的加工特征模型数据集对网络进行训练,对加工特征模型进行测试,得到很好的识别效果。

关键词： cardiac metastases   cardiac tumors   squamous cell carcinoma   tongue carcinoma   anti-LAG-3   anti-lymphocyte activation gene 3   anti-TIM-3   anti-T-cell immunoglobulin and mucin domain-containing protein 3   CAD   coronary artery disease   CMR   cardiac magnetic resonance   ECG   electrocardiogram   EF   ejection fraction   EMB   endomyocardial biopsy   FDG   F-18 fluorodeoxyglucose   LV   left ventricle   LVEDP   left ventricular end-diastolic pressure   MRI   magnetic resonance imaging   pan-CT   whole-body computed tomography   PD-1   programmed cell death-1   PET/CT   positron emission tomography/computed tomography   SCC  

摘要： A 60-year-old man with squamous cell carcinoma of the tongue had atypical chest pain and mild troponin elevation. No significant electrocardiogram changes or arrhythmias were noted. Cardiac magnetic resonance revealed several myocardial metastases with pericardial involvement, confirmed by positron emission tomography/computed tomography. Unsuitable for surgery, he was referred for palliative chemotherapy.

关键词： 靛蓝染整技术   纺织品染色   工艺优化   创新应用  

摘要： 靛蓝染是一种传统染色工艺,在纺织品染色中一直占有重要地位。随着现代科技的不断发展,靛蓝染整技术在染料的合成、染色工艺的优化等方面进行了创新,但在染色精度、染料利用率和生产环境方面仍有很大的提升空间。分析靛蓝染整工艺中的关键技术突破及其在不同纺织品上的应用案例,探讨如何通过优化现有技术推动靛蓝染整技术的可持续发展。

关键词： Ethnomedicine   Herbal medicine   Complementary and alternative Medicine (CAM)   Gastroenterology and hepatology disorders   Traditional Persian medicine   CAM   Complementary and alternative medicine   FD   Functional dyspepsia   FGID   Functional gastrointestinal disorders   GERD   Gastroesophageal reflux disease   IBS   Irritable bowel syndrome   PUD   Peptic ulcer disease   QOL   Quality of life  

摘要： The role of complementary and alternative medicine (CAM) in healthcare is substantial and frequently overlooked, with widespread use in both developed and developing countries. This study aimed to explore the ethnomedicinal knowledge including prevalence, socio-demographic, and health related characteristics related to gastroenterology and hepatology disorders in Kerman province.

关键词： 纺织品贸易   复杂网络   指数随机图模型   国际贸易   贸易网络演化  

摘要： 本文通过指数随机图模型研究2006—2021年全球纺织品贸易网络的演化及其影响因素。研究发现,贸易网络整体呈稳定上升趋势,连通性和互动性增强。中国、印度在出口方面占主导地位,而美国和欧洲国家在进口方面表现稳定。经济水平较低的国家之间以及人口规模适中的国家之间更容易形成贸易关系,而创新水平较高的国家间贸易关系更加紧密。地理邻接、共同语言、宗教相似程度高和签订自由贸易协定对贸易网络形成有显著促进作用,地理邻接的影响尤为突出。本文为全球纺织品贸易网络的演化机制提供了新的研究视角,旨在为制定贸易政策和优化贸易结构提供重要的参考依据。

关键词： Cardiodiabetology   Cardiovascular risk   Glucose   Triglycerides   Triglyceride-glucose index   TyG   ACE   Angiotensin-Converting Enzyme   ADP   Adenine Diphosphate   AGEs   Advanced Glycation End Products   AH   Arterial Hypertension   ANP   Atrial Natriuretic Peptide   ATP   Adenosine Triphosphate   baPWV   Brachial-Ankle Pulse Wave Velocity   BNP   Brain Natriuretic Peptide   BMI   Body Mass Index   CAD   Coronary Artery Disease   CKD   Chronic Kidney Disease   CVD   Cardiovascular Disease   DM2   diabetes mellitus 2   eGFR   Estimated Glomerular Filtration Rate   FAD   Flavin Adenine Dinucleotide   FBG   fasting blood glucose   FFA   Free Fatty Acids   GLP-1   Glucagon-Like Peptide-1   HF   Heart Failure   IL   Interleukin   IR   Insulin Resistance   LV   Left Ventricular   MACE   Major Adverse Cardiovascular Events   MetS   Metabolic Syndrome   NAD   Nicotinamide Adenine Dinucleotide   NADPH   Nicotinamide Adenine Dinucleotide Phosphate   NLRP3   NOD-Like Receptor Family Pyrin Domain Containing 3   NO   Nitric Oxide   RAAS   Renin-Angiotensin-Aldosterone System   ROS   Reactive Oxygen Species   SGLT2i   Sodium-Glucose Cotransporter 2 Inhibitors   T2DM   Type 2 Diabetes Mellitus   Tg   triglycerides   TGRLs   Triglyceride-Rich Lipoproteins   TLR4   Toll-Like Receptor 4   TyG   Triglyceride Glucose Index   UACR   Urine Albumin-to-Creatinine Ratio   VLDL   Very Low-Density Lipoprotein  

摘要： In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance.

关键词： 纺织品   艺术设计   数码印花   印花图案  

摘要： 数码印花图案在纺织品艺术设计中的应用,大幅提升了纺织品艺术设计的灵活性,使设计师能够突破传统设计思维限制,实现更多的创意表达,精准捕捉并满足现代消费者对于个性化纺织品的需求,促进纺织品艺术设计的创新发展。数码印花图案可通过单一工艺应用于纺织品,也可与手绘艺术、刺绣工艺等相结合,丰富纺织品艺术设计层次与质感。为实现数码印花图案与纺织品艺术设计的完美融合,应不断优化数码印花图案的工艺,提升设计团队的数字化设计能力,并加强印花工艺与色彩管理控制,确保设计作品的高品质呈现,推动纺织品艺术设计领域的繁荣发展。

关键词： ACC   American College of Cardiology   ACEI   angiotensin-converting enzyme inhibitor   AHA   American Heart Association   AI   aromatase inhibitors   ARB   angiotensin receptor blocker   ASCO   American Society of Clinical Oncology   ASCVD   atherosclerotic cardiovascular disease   BC   breast cancer   BMI   body mass index   CAD   coronary artery disease   CDK4/6i   cyclin-dependent kinase 4/6 inhibitor   CHF   congestive heart failure   CORE   CardioOncology Rehabilitation   CV   cardiovascular   CVD   cardiovascular disease   ECG   electrocardiographic   HF   heart failure   HTN   hypertension   LDL-C   low-density lipoprotein cholesterol   LVEF   left ventricular ejection fraction   MI   myocardial infarction   OFS   ovarian function suppression   OR   odds ratio   PARP   poly-ADP-ribose polymerase   PCP   primary care physician   PD-1   programmed death-1   RF   risk factors   RT   radiotherapy   TNBC   triple-negative breast cancer   T-DM1   trastuzumab emtansine  

摘要： Breast cancer (BC) survivors are at increased risk for cardiovascular disease (CVD) and require their primary care physicians to manage their long-term general medical care, including cardiovascular (CV) health. Yet, evidence exists that some primary care physicians possess insufficient knowledge about survivorship care. With the goal of bridging these knowledge gaps, a PubMed review was conducted from July 7, 2020, through October 2, 2020, with an updated PubMed review from January 3, 2024, through April 28, 2024, focusing on CV health considerations in the primary care of BC survivors. Search terms included variations of “breast cancer survivors” and “cardiovascular.” In total, 152 publications were included. Breasts cancer survivors may have increased CVD risk because some anticancer therapies are cardiotoxic and risk factors for BC often also increase the risk for CVD. Multiple risk factors overlap for BC and CVD such as older age, Western diet, early menarche, physical inactivity, high body mass index, and smoking. In this review, results are summarized from studies that report the presence of CV risk factors and CVD in BC survivors. Also described are the CV effects of BC therapies (chemotherapy, hormonal agents, targeted therapies, and radiotherapy) and the type of CV evaluation (cardiac imaging and measurement of biomarkers) that these patients may need. Primary care physicians have an important role in managing the CV health of BC survivors from preventing, assessing, and managing CV risk factors to referring patients to appropriate specialists when needed.