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关键词： 金属材料   2024铝合金   双轴肩搅拌摩擦焊   热循环   组织及性能  

摘要： 采用双轴肩搅拌摩擦焊(Bobbin tool friction stir welding,BT-FSW)对4 mm厚2024铝合金进行焊接,研究了焊接热循环温度对焊缝组织与性能的影响。结果表明:后退侧峰值温度高于前进侧,温度差约为20℃;焊核区平均晶粒尺寸为10.1μm,后退侧各区域平均晶粒尺寸大于前进侧,小角度晶界占比小于前进侧;焊核区形成了细小的沉淀相S相,热影响区沉淀相数量减少和尺寸的增加导致力学性能下降;接头显微硬度呈“W”型分布,后退侧热机影响区与热影响区交界处硬度值最小,约为72.3 HV。

关键词： 教学改革   纺织品贸易   产教融合   供应调整  

摘要： 文章基于纺织品贸易与跟单课程教学改革的探究,强调了全球经济一体化和数字化技术发展对纺织品贸易行业的影响,以及对从业人员的新要求。通过对全球供应链调整、技术创新、可持续性、区域贸易协定、新兴市场崛起和贸易摩擦等因素对教育影响的分析,指出了传统教育模式的不足,并提出了改革措施,如提升教师水平、更新教学内容、创新教学方法、加强产教融合、拓展跨学科和强化对技术贸易壁垒的认识,旨在培养适应国际贸易和科技发展变化的高素质纺织品贸易跟单人才。

关键词： 产品设计   纺织品   敦煌文化   历史底蕴   文化创意  

摘要： 在全球化的背景下,传统文化的保护与传承成为设计领域的一个重要议题。产品设计不仅仅是功能性和美观性的体现,更是文化传承与创新的载体。文章以“丝绸之路”上的敦煌为例,探讨产品设计者如何在尊重和继承传统文化的基础上,同时以纺织品为例进行创新设计,以实现文化与现代生活的和谐融合。

关键词： 镜像翻转   穿龈轮廓   软组织   临时冠   美学分析  

摘要： 目的:对比传统法临时冠和镜像翻转法临时冠在前牙种植软组织塑形方面的效果,为提升前牙种植美学效果提供参考。方法:选取2022年1月~2022年12月就诊于河北医科大学口腔医院修复科行单颗前牙种植病例50例,二期手术时按照随机原则分为传统组(n=25)采用传统技术制作临时冠并行软组织塑形,镜像组(n=25)采用镜像翻转+CAM打印临时冠。对比即刻修复时与1个月临时冠塑形后美学修复效果与软组织形态。结果:镜像翻转+CAM在临时冠塑形修复后的美学效果优于传统法,修复后1个月镜像组近、远中牙龈乳头高度相比即刻修复明显增加(P<0.05),传统组未见明显改变(P>0.05);且红色美学评分(pink esthetic score,PES)高于传统组。结论:镜像翻转+CAM复制并模拟天然牙的颈部穿龈形态,可以控制穿龈袖口形状和维持软硬组织的形态,获得可预期的美观效果和牙周健康,同时简化现有制作步骤,缩短疗程,为前牙种植修复的软组织塑形重建和维持提供一定的临床参考。

关键词： Attention channel mechanism   Blastocyst grading   Classification model   Deep learning   In-vitro fertilisation   Navigator-teacher-scrutinizer  

摘要： An automated-based intelligence approaches have widely used for quantifying In-Vitro Fertilisation (IVF) blastocyst image features that offer automation in morphology assessment as well as embryo selection to improve embryo implantation. Since the IVF blastocyst co-existed three main features of Zona Pellucida (ZP), Trophectoderm (TE) and Inner Cell Mass (ICM), this has made it crucial to consider the informative regions of all features in image morphology assessment. Although the implementation of Navigator-Teacher-Scrutinizer Network (NTS-net) has been detected most informative regions under the guidance of the Teacher network, there still limitation on calculation of the feature extraction process of different blastocyst features that led to poor classification performance. Therefore, this study proposes a new classification model namely NTS-CAM to improve extracted blastocyst features by assigning weights to channel features in channel attention mechanism (CAM) while extracting informative regions of each blastocyst feature. The benchmarking dataset showed significant performance of classification accuracy for ZP, TE, and ICM features with 80.5 %, 67.4 %, and 76.3 %, and the clinical dataset showed 74.1 %, 71.8 %, and 63.5 %, respectively. In conclusion, the proposed NTS-CAM model to predict grade of IVF blastocyst quality has improved the performance compared to classic NTS model. Furthermore, the improved model can be used for clinical decision making as well as for quality control in IVF procedure. © 2024 Elsevier GmbH

关键词： 纺织集团   展览会开幕   产业用纺织品   创新亮点   新材料技术   控股公司   非织造布   孙瑞哲  

摘要： 9月19日—21日,2024年第十七届中国国际产业用纺织品及非织造布展览会(CINTE)在上海浦东新国际博览中心举行。400余家展商汇聚一堂,共同探索信息时代产业用纺织品的发展方向与商机。北京光华纺织集团有限公司旗下的北京佳泰新材料有限公司、北京中纺海天新材料技术有限公司、北京燕阳新材料技术发展有限公司,北京清河三羊毛纺织集团有限公司旗下的北京京兰非织造布有限公司等企业集中亮相,拳头产品各具特色,展示在产业用纺织品及非织造布领域“高精尖”创新亮点。展览会开幕当天,中国纺织工业联合会会长孙瑞哲,秘书长夏令敏,副会长徐迎新、李陵申,中国产业用纺织品行业协会会长李桂梅等领导也莅临展位参观,并对北京时尚控股有限责任公司(以下简称“北京时尚控股公司”)科技与时尚融合及创新发展成果给予了高度赞赏和充分肯定。北京时尚控股公司党委常委、常务副总经理赵宏晔陪同。

关键词： Collagen type VIII   Collagen VIII   COL8A1   Vascular disease   Extracellular matrix   Angiogenesis   Vascular remodeling   ECM   COL8   COL8A1 collagen type VIII alpha 1 chain   COL8A2   COL8A1 collagen type VIII alpha 2 chain   FACIT   Fibril-associated collagens with interrupted triple helices   EC   Endothelial cell   NC1   Non-collagenous C-terminal domain   NC2   Non-collagenous N-terminal domain   TMA   Tissue microarray   PDAC   Pancreatic ductal adenocarcinoma   C8-C, C-terminal end of COL8A1   ANOCA, Angina with no obstructive coronary artery disease   CAD   Coronary artery disease   DN   Diabetic nephropathy   BNS   Benign nephrosclerosis   FSGS   Focal-segmental glomerulosclerosis   RHF   Right heart failure   CTEPH   Chronic thromboembolic pulmonary hypertension   SMC   Smooth muscle cell   Apoe   Apolipoprotein E-deficient   EMT   Epithelial to mesenchymal transition   ITGB1   β1 integrin   DDR1   Discoidin domain receptor tyrosine kinase 1   MAPK   Mitogen-activated protein kinase   TGF-β   Transforming growth factor-β   RhoA   Ras homolog family member A   MMP   Matrix metalloproteinase   FAK   Focal adhesion kinase   PI3K   Phosphoinositide 3-kinase   SMAD   Small mothers against decapentaplegic   EndMT   Endothelial to mesenchymal transition  

摘要： Collagens have dual functions in the extracellular matrix (ECM), acting as both structural components and signaling molecules in matricellular communication. Although collagen molecules share a common triple helix motif, the supramolecular organization helps classify them into nearly 30 different types of collagens. Collagen type VIII is a non-fibrillar, short-chain, network-forming collagen that is expressed throughout the vasculature. Collagen VIII expression is aberrant in cardiovascular, lung, and renal disease, as well as in several different types of cancer. It plays active roles in angiogenesis, vessel injury repair, maintenance of arterial compliance, atherosclerotic plaque formation and stability modulation, fibrosis, and ECM remodeling. This review presents an overview of the characteristics of collagen VIII in vascular-related disorders, from clinical significance to laboratory studies, with a major focus on highlighting the signaling properties of collagen VIII in the vascular ECM. The expression patterns of collagen VIII in human diseases and experimental animal models highlight the protein's important yet underexplored functions. A deeper understanding of its mechanisms and downstream signaling pathways may pave the way for translational and tissue engineering applications of collagen VIII.

关键词： transcatheter aortic valve replacement   surgical aortic valve replacement   low-risk   self-expandable   balloon-expandable   CAD   coronary artery disease   IPD   individual patient data   MI   myocardial infarction   PPI   permanent pacemaker implantation   PRISMA   preferred reporting items for systematic reviews and meta-analyses   PVL   para-valvular leak   RCT   randomized controlled trials   SAVR   surgical aortic valve replacement   TAVR   transcatheter aortic valve replacement   THV   transcatheter heart valve  

摘要： AbstractTranscatheter aortic valve replacement (TAVR) is a safe and effective treatment option for patients with severe aortic stenosis at intermediate or high surgical risk. Results after TAVR in low-risk patients are very encouraging at mid-term follow-up while limited long-term (≥ 3-year) data are available in this subset of patients. This meta-analysis aims to compare the long-term follow-up after TAVR versus surgical aortic valve replacement (SAVR) in low-risk patients. We searched databases up to July 7 th 2024, for randomized clinical trials (RCTs) comparing TAVR versus SAVR in low-risk patients (defined as STS-PROM Score less than 4%). (PROSPERO ID: CRD42023480495). Primary outcome analysed was all-cause death at minimum 3-year follow-up. Secondary outcomes were: cardiovascular death, disabling stroke, myocardial infarction (MI), aortic valve reintervention, endocarditis, new-onset atrial fibrillation, permanent pacemaker implantation (PPI) and bioprosthetic valve failure (BVF). A total of 3 RCTs with 2,644 patients (TAVR, n=1,371 patients; SAVR, n=1,273 patients) were included. Follow-up time was 6 ± 2.9 years. TAVR resulted non-inferior to SAVR for all-cause death [RR: 0.99 (95% CI: 0.84-1.17; p=0.89; I 2=28%)], cardiovascular death [RR: 0.94 (95% CI: 0.76-1.15; p=0.54; I 2=0%)], MI [RR: 1.06 (95% CI: 0.71-1.57; p=0.79; I 2=61%)], aortic valve reintervention, endocarditis and BVF. New-onset atrial fibrillation was higher in the SAVR group, while PPI in the TAVR group. In conclusion our meta-analysis showed that TAVR is associated with similar long-term outcomes compared to SAVR in selected, low-risk patients.

关键词： 矿用圆环   驱动链轮   CAD   齿形加工  

摘要： 介绍一种矿用圆环驱动链轮齿形的加工方法,首先采用CAD作图法分析各直线和圆弧的相关基点,再计算直线方程式的编程参数,分别采用了FANUC 180i系统用户的宏程序功能和SIEMENS 840D系统的R代码功能,既提高了链轮的加工质量,又降低了加工成本。

关键词： 类器官   器官培养   神经生物学   水凝胶   Matrigel   Cell   细胞命运   神经元  

摘要： 近日,一篇发表在《Cell Rep》上的研究报告显示,通过对Matrigel和N-cadherin肽功能化明胶甲基丙烯酰水凝胶(GelMA-Cad)在皮质神经类器官培养中的作用进行对比,发现肽的呈现能够调节分化过程中的细胞命运和多样性,GelMA-Cad培养的类器官更贴近人类胎儿群体,神经元的自发兴奋性突触后电流更多,这证明基质连接的信号肽可影响分化,GelMA-Cad可作为Matrigel的替代物用于神经类器官培养。此项研究为培养提供更优基质,有助于提高细胞代表性,对神经生物学和疾病建模具有重要意义,同时也为开发其他水凝胶提供了思路。