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关键词： Coronary microvascular dysfunction   Coronary flow reserve   Microvascular resistance reserve   Index of microcirculatory resistance   Aging   ANOCA   Angina with no obstructive coronary arteries   CAD   Coronary artery disease   CFR   Coronary flow reserve   CMDR   Coronary Microvascular Disease Registry   CMD   Coronary microvascular dysfunction   IMR   Index of microcirculatory resistance   MRR   Microvascular resistance reserve   PCI   Percutaneous coronary intervention  

摘要： Coronary microvascular dysfunction (CMD) contributes to angina without obstructive coronary artery disease (ANOCA). Although aging is known to impact cardiovascular health, its effect on coronary microvascular function remains unclear. This study examined the relationship between age and microvascular function in patients with ANOCA.

关键词： FOSL2   L1CAM   LUAD   PI3K/AKT/mTOR   Transcription factor  

摘要： Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality, largely due to its aggressive behavior and early metastatic potential. In this study, FOS-like 2 (FOSL2) was identified as a transcriptional regulator that upregulates L1 cell adhesion molecule (L1CAM) in LUAD. L1CAM was found to be upregulated in LUAD cell lines compared to non-malignant lung epithelial cells. Functional assays demonstrated that silencing L1CAM reduced cell proliferation, migration, and invasion, increased apoptosis, and inhibited activation of the PI3K/AKT/mTOR pathway. Suppression of FOSL2 produced similar effects in vitro and also limited tumor growth in vivo. Treatment with the AP-1 inhibitor T5224 reduced proliferation of A549 cells. Moreover, knockdown of L1CAM attenuated the tumor-promoting effects of FOSL2 overexpression, indicating that L1CAM contributes to the oncogenic activity of FOSL2, possibly by mediating activation of the PI3K/AKT/mTOR signaling pathway.

摘要： The objective of this study was to evaluate the in vivo transfer accuracy of a new slim and rigid computer-aided design and manufacturing (CAD-CAM) transfer tray.

关键词： 废旧纺织品   循环利用   标准体系   标准化建设  

摘要： 为了研究湖州市废旧纺织品循环利用标准体系,优化完善废旧纺织品循环利用建设工作的顶层设计,文章梳理了国内外废旧纺织品循环利用标准化研究现状,重点调研了湖州市废旧纺织品产业及标准化建设实际,查找出现阶段标准化建设存在的问题。在此基础上,研究建立了湖州市废旧纺织品循环利用标准体系框架及主要标准化建设内容。充分发挥标准化的战略性和基础性作用,提出标准化建议和实现路径,为全国废旧纺织品循环利用相关研究提供了标准化经验。

关键词： OBE   CBL   TBL   双轨教学   机械CAD/CAM   教学改革  

摘要： 在智能制造与工业4.0浪潮下,机械领域对具备实践能力与协同创新素养的CAD/CAM人才需求迫切,而传统课程存在严重的理论与实践脱节问题,难以适配行业发展需求,课程改革刻不容缓。本文构建基于成果导向(OBE)的CBL-TBL双轨教学法,以企业真实零件设计与加工案例为载体,设计“案例拆解-小组分工协同-成果互评”教学流程,将行业规范融入各环节,并建立涵盖过程表现与工程应用能力的多元评价体系。实践表明,该模式有效打破软件操作导向的教学惯性,强化学生工程思维与团队协作能力,为机械类课程实现“知识-技能-素养”协同育人提供可行路径。

关键词： 纺织品   闪粉   烫金   质量   标准  

摘要： 印(烫)闪粉的纺织品在洗涤、熨烫、摩擦、储存等日常使用过程中,闪粉容易脱落,表面结构受损,严重影响产品质量,消费者投诉较多。现行的国内外标准未涵盖纺织品闪粉牢固性能的检测与评价,无法统一规范产品质量,因此建立纺织品闪粉牢固性能的检测与评价方法迫在眉睫。通过模拟纺织品洗涤、熨烫、摩擦、储存等使用场景,测试闪粉的牢固性能,探索建立一种有效的检测方法,以填补纺织品闪粉牢固程度检测的空白,该方法既有助于纺织服装企业进行质量控制,防止质量问题的发生,也可为产品质量评价提供依据,保护消费者的合法权益。

关键词： 智能制造   创新创业教育   CAD课程   教学改革  

摘要： 基于国家创新创业教育战略导向和智能制造产业升级需求,文章分析了CAD课程传统教学中存在的问题。构建了“三维三阶”教学模式,通过引入企业真实生产案例重构内容,采用工程任务驱动与跨学科协作教学法,并建立多维度评价体系,实现贯穿教学全过程的能力培养。实践表明,教学改革有效提升了学生的创新创业能力和工程实践能力,可为同类课程改革提供有益参考。

关键词： Spring ligament instability   Flatfoot   Progressive collapsing foot deformity   Biomechanics   Reconstruction  

摘要： El ligamento calcaneonavicular (spring ligament) juega un papel fundamental en la estabilidad estática calcaneonavicular y el arco longitudinal medial, cuya lesión se relaciona con el pie plano.

关键词： Laccase   cinnamyl alcohol dehydrogenase   Gene family   Bioinformatics   Expression pattern   Transgenic technology   Populus simonii  

摘要： This study presents the first genome-wide identification and comprehensive analysis of laccase (LAC) and cinnamyl alcohol dehydrogenase (CAD) gene families in Populus simonii, revealing 39 PsiLAC and 18 PsiCAD members. Phylogenetic and structural analyses classified these genes into distinct subfamilies, highlighting conserved motifs and evolutionary divergence. Tissue-specific expression patterns demonstrated high activity in roots, leaves, and apex, while abiotic stress responses implicated their roles in drought and salt tolerance. Since the knockout of COMT leads to the accumulation of the C-lignin precursor (caffeyl alcohol), we chose the COMT-KO line as the background. Additionally, research results on Cleome hassleriana showed that CAD5 has a higher affinity for caffealdehyde and can specifically catalyze the reduction of caffeoyl-CoA (caffeoyl coenzyme A) to caffeyl alcohol. This allows LAC8 to promote the polymerization of caffeyl alcohol to form C-lignin. A groundbreaking achievement was the construction of a PsiLAC8-PsiCAD5 tandem gene module, which was transformed into COMT-KO poplar lines. Transgenic plants exhibited elevated lignin content and altered phenotypes, providing functional evidence for their involvement in lignin polymerization. This work not only advances understanding of lignin biosynthesis in woody plants but also establishes a foundation for engineering C-lignin production in Populus, offering novel strategies for improving biomass utilization and stress resilience. The integration of bioinformatics, expression profiling, and transgenic validation underscores the dual functional significance of PsiLAC8-PsiCAD5 in lignin synthesis and stress adaptation.

关键词： 双循环格局   供应链   组织结构变革   能力匹配  

摘要： 本文深入剖析了当前我国企业供应链高质量发展面临的问题和挑战,重点围绕优化供应链空间布局,推进企业供应链组织结构扁平化,打造弹性供应链与风险免疫体系,持续推动供应链数字化转型,积极构建企业供应链网络化协同体系等方面,提出了推动企业供应链组织结构变革,构建适应与双循环发展格局相匹配的供应链的具体措施,对于形成良好的企业供应链发展生态,实现企业高质量发展具有积极意义。