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关键词： 帕拉米韦注射液   高效液相色谱   电喷雾检测器   杂质谱解析   有关物质  

摘要： 目的:建立HPLC-CAD法测定帕拉米韦注射液的有关物质,并对降解杂质进行杂质谱解析。方法:采用Welch Ultimate Polar RP柱(250 mm×4.6 mm,3.5μm),以5 mmol·L^(-1)甲酸铵溶液(用甲酸调pH至4.6)-乙腈(B)(95∶5)为流动相A,流动相A-乙腈(50∶50)为流动相B,梯度洗脱,体积流量为0.8 mL·min^(-1),柱温30℃,CAD雾化器温度50℃,采集频率5 Hz,滤光片3.6 s。通过LC-MS/MS,推测帕拉米韦的降解途径及杂质结构。结果:帕拉米韦与各杂质之间分离度良好,帕拉米韦与7个杂质的质量浓度约在0.2~12μg·mL^(-1)与峰面积呈良好的线性关系,定量限为4.32~12.8 ng,检测限为2.16~6.44 ng;杂质Ⅲ的平均回收率(n=9)为96.2%,RSD为1.8%;对照溶液和供试品溶液在室温条件下放置102 h内稳定;微调液相色谱参数后,对有关物质的检测结果无影响。根据LC-MS/MS,推测了降解杂质的结构及可能的降解途径。结论:该方法用于测定帕拉米韦注射液的有关物质准确、可靠,专属性强,为建立该品种质量标准提供研究基础。

关键词： 北魏   鎏金铜带銙   纺织品残留物   微观形貌观察   结构分析   酶联免疫技术  

摘要： 大同交通苑北魏墓群出土的鎏金铜带銙的銙片中夹杂少许纺织品残留物。为从科学角度了解其材质和劣化情况,利用超景深三维显微系统、扫描电镜-能谱分析仪、红外光谱分析、酶联免疫方法对纺织品残留物进行了微观形貌观察和结构分析,并对纤维材质进行鉴别。采用多种手段综合考量纺织品残留物的结构特点和组成成分,可更准确地辨别材质种属,提高结果的可信度。检测分析表明鎏金铜带銙内部夹杂的纺织品为桑蚕丝,这不仅对北魏时期北方民族丝织文物的考古历史研究有重要意义,而且为北魏时期带具的组合形制及带鞓的材质提供了科学依据。

关键词： 佩鲁贾长巾   东方风格   铭文纺织品  

摘要： 佩鲁贾长巾是14—16世纪意大利地区的一种日用纺织品,屡见于意大利的文献和图像中,并表现出明显的东方特征。这种现象源自东方织物在意大利市场的优势地位。同时,长巾上的铭文等东方母题被替换为了西方样式,标志着东方风格的脱离,且此现象在之后的意大利纺织品中更为明显,经济、文化等多种因素共同导致了这一结果。

关键词： CAM   Semantic segmentation   Single-stage   Weakly supervised learning  

摘要： Weakly supervised semantic segmentation with image-level annotations usually adopts multi-stage approaches, where high-quality offline CAM is generated as pseudo labels for further training, leading to a complex training process. Instead, current single-stage approaches, directly learning to segment objects with online CAM from image-level supervision, are more elegant. The quality of CAM critically determines the final segmentation performance. However, how to generate high-quality online CAM has not been deeply studied in existing single-stage methods. In this paper, we propose a new single-stage framework to mine more relative target features for enhanced online CAM. Specifically, we design a novel Collaborative Guidance Mechanism, where a prior guidance block uses the original CAM to produce class-specific feature representations, improving the quality of online CAM. However, such a prior is sensitive to discriminative regions of objects. Thus, we further propose a prior fusion block, in which the online segmentation prediction and the original CAM are fused to strengthen the prior guidance. Extensive experiments show that our approach achieves new state-of-the-art performance on both PASCAL VOC 2012 and MS COCO 2014 datasets, outperforming recent single-stage methods by a clear margin. Code is available at https://***/1rua11/CGM © 2024 Elsevier Ltd

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关键词： 纤维微塑料   纺织品   环境污染   洗涤烘干   检测方法  

摘要： 纺织品家庭清洁过程是纤维微塑料环境污染的重要来源之一。综述了纺织品在家庭洗涤和烘干过程中释放纤维微塑料的现象及其对环境和人类健康的潜在影响,分析了洗涤烘干条件(如温度、时间、水量、转速等)对纤维微塑料释放的影响,研究发现提高温度、增加机械作用强度以及延长洗涤时间均会增加纤维微塑料的释放量。现有检测方法在标准化方面存在不足,影响了研究结果的可比性和重复性。基于此,强调了开发敏感高效的纤维微塑料监测技术和减少纤维微塑料释放策略的重要性,并提出功能性纺织品开发及纤维微塑料拦截技术的创新方向。这些措施对于减轻微塑料污染、保障公众健康具有重要意义。

关键词： Surface reconstruction   Feature lines   Point cloud enhancement   CAD models  

摘要： Feature lines play a pivotal role in the reconstruction of CAD models. Currently, there is a lack of a robust explicit reconstruction algorithm capable of achieving sharp feature reconstruction in point clouds with noise and non-uniformity. In this paper, we propose a feature-preserving CAD model surface reconstruction algorithm, named FACE. The algorithm initiates with preprocessing the point cloud through denoising and resampling steps, resulting in a high-quality point cloud that is devoid of noise and uniformly distributed. Then, it employs discrete optimal transport to detect feature regions and subsequently generates dense points along potential feature lines to enhance features. Finally, the advancing-front surface reconstruction method, based on normal vector directions, is applied to reconstruct the enhanced point cloud. Extensive experiments demonstrate that, for contaminated point clouds, this algorithm excels not only in reconstructing straight edges and corner points but also in handling curved edges and surfaces, surpassing existing methods. © 2024 The Author(s)

关键词： clinical metric   health-related quality of life   home-based cardiac rehabilitation   participation rate   risk factor   CAD   coronary artery disease   CBCR   center-based cardiac rehabilitation   CR   cardiac rehabilitation   CVD   cardiovascular disease   HBCR   PHQ-9   The Patient Health Questionnaire   QoL   quality of life   RYP   Rate Your Plate  

摘要： Few studies have evaluated home-based cardiac rehabilitation (HBCR) during the pandemic, compared to prepandemic center-based CR (CBCR), with respect to patient characteristics, participation rates, and its efficacy on clinical metrics, health-related quality of life (QoL), and modifiable risk factors.

关键词： 纺织品   纳米材料   机械性能   抗菌防臭  

摘要： 现代纺织业的不断发展对纺织品的功能与性能提出了更多要求。传统纺织品受限于材料本身,很难完全满足新时期背景下人们对纺织品的多样化要求。在纺织品中应用纳米材料,凭借纳米材料自身的独特性能与优势改善纺织品性能,无疑能为纺织品发展提供创新支持与进步动力。文章对纳米材料进行了简单介绍,并围绕抗拉强度、抗撕裂强度、弹性模量、耐磨损性、抗菌防臭、防紫外线、智慧纺织品等维度,探讨纺织品中纳米材料的应用情况。