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关键词： Murray law-based quantitative flow ratio   completeness of revascularization   coronary artery disease   pullback pressure gradient index   quantitative flow ratio  

摘要： Focal stenotic coronary lesions, as defined by the invasive pullback pressure gradient index (PPGI) measured before percutaneous coronary intervention (PCI), are associated with less residual angina than diffuse lesions as assessed by the Seattle Angina Questionnaire (SAQ).

关键词： 工业软件   国产化   制造业   CAD   CAE   卡脖子   MBSE  

摘要： 问题入口:制造业“卡脖子”背后,工业软件的突围之困工业软件是产品全生命周期的“灵魂”,当前MBSE、CAD、CAE等核心品类被欧美企业垄断,我国面临技术“卡脖子”、研发成本高、数据安全无保障等问题。本文梳理了工业软件应用现状与国产化瓶颈,为突围之路提供了清晰指引。

摘要： A chairside light-polymerized hard relining material has been developed to overcome the limitations of autopolymerizing resins that include the exothermic reaction, odor, and prolonged polymerization time. However, its adhesion to computer-aided design and computer-aided manufacturing (CAD-CAM) denture base materials remains unclear.

关键词： 经编织物膜材   平面张拉结构   模态试验   低真空环境   空气环境   拉剪耦合  

摘要： 由织物膜等高强度膜材构成的膜结构在建筑结构、航空航天和海洋工程等领域皆有重要应用,其振动特性的改变将直接影响结构的安全性与可靠性。为了研究拉剪耦合与环境空气对织物膜结构振动模态的影响规律,完善了前期研究的低真空模态试验系统,开展了织物膜材平面张拉膜结构的模态试验,考虑了环境气压、预张力、应力比、纱线偏轴角度等因素,分析了织物膜振动的空气敏感性以及拉剪耦合效应等对结构振动特性的影响。试验与分析结果表明:织物膜振动的空气敏感性与均质膜对比相对较低,低真空环境下模态频率增幅为34.73%;其振动频率与预张力水平正相关,增幅最大为69.77%;拉剪耦合效应也会影响振动频率,其中偏轴角度还会改变模态振型。研究成果将为薄膜结构的模态分析提供重要理论依据与试验保障。

摘要： C. Fan, C. Hao, L. Liu, et al., “Radiotherapy and Cardiovascular Disease Survival Risk in Non-Small Cell Lung Cancer: A Population-Based Study from the Surveillance, Epidemiology, and End Results Database,” Cancer Medicine 15, no. 6 (2026): e71965, https://***/10.1002/cam4.71965. The author order was incorrect and has been changed from Li Liu, Chunhui Fan, Wenxin Ren, Mingyi Wen, Cunqi Li, Cuiping Hao, Yian Geng, Liping Zhang to Chunhui Fan, Cuiping Hao, Li Liu, Mingyi Wen, Cunqi Li, Yian Geng, Wenxin Ren, Liping Zhang. The online version of this article has been corrected accordingly. We apologize for this error. © 2026 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.

关键词： ALSP   axonal spheroids and pigmented glia   ATM   axon tract–associated microglia   CAM   central nervous system-associated macrophage   Cl-Casp3   cleaved caspase-3   CNS   central nervous system   CSA   cortico-striato-amygdalar boundary   CSF1   colony-stimulating factor 1   CSF1R   colony-stimulating factor 1 receptor   E   embryonic day   GE   ganglionic eminence   Hexb   hexosaminidase subunit beta   IL-34   interleukin-34   iPSC   induced pluripotent stem cell   MACS   magnetic-activated cell sorting   P2RY12   purinergic receptor P2Y12   Siglec-H   siglech sialic acid binding Ig-like lectin H   Spp1   secreted phosphoprotein 1   WT   wild-type   Brain   Microglia   Transplantation   Development   Embryo   Engraftment   Ganglionic eminence   Pallium  

摘要：

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  Transient microglial depletion enhances engraftment in the embryonic brain.
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  A CSF1R inhibitor creates a permissive environment for donor microglial infiltration.
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  Transplanted microglia partially rescue developmental structural abnormalities.

关键词： AI   CAD制图课程   教学模式改革  

摘要： 在教育和科学技术相互渗透的大背景下,AI为CAD制图课程引入个性化的教学方式,既能满足产业对专业人才的需求,又能增强毕业生在就业市场中的竞争力,提高教学质量和工作效率。文章通过对AI赋能CAD制图课程的现状进行剖析,并提出相应的对策,能使整个教学质量得到全方位的提升,最终为产业培养出高质量、满足现实需要的专业人才。

关键词： ACSS1   ACSS2   ACLY   CAD   DHODH   Acetate metabolism   Oncometabolite   Cancer metabolism  

摘要： Acetate serves as an alternative carbon source in nutrient-limited tumors, yet its role in supporting nucleotide biosynthesis remains poorly understood. Here, we identify the mitochondrial enzyme ACSS1 as a key metabolic driver in mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and chronic lymphocytic leukemia (CLL). ACSS1 is frequently overexpressed and catalyzes the conversion of acetate to mitochondrial acetyl-CoA, sustaining oxidative metabolism and biosynthesis under nutrient stress. Genetic silencing of ACSS1 impairs mitochondrial respiration and disrupts acetate incorporation into acetyl-CoA, TCA cycle intermediates, glutamate, and aspartate, while markedly reducing ¹³C-acetate labeling of dihydroorotate and orotate, intermediates in de novo pyrimidine synthesis. Untargeted metabolomics reveal enrichment of pyrimidine biosynthesis pathways in ACSS1-high cells. Notably, acetate or uridine supplementation rescues the growth of ACSS1-deficient cells, confirming a functional link between acetate metabolism and nucleotide synthesis. Importantly, in vivo studies using two different MCL xenografts demonstrate that ACSS1 knockdown profoundly suppresses tumor growth, indicating that ACSS1 is required not only for metabolic adaptation of lymphoma cells in vitro but also in vivo. Collectively, our results uncover an ACSS1-dependent mitochondrial acetate–pyrimidine axis that sustains lymphoma growth and represents a previously unrecognized therapeutic vulnerability.

关键词： 工业增加值   产业用纺织品   经济增长  

摘要： 2026年1—5月,全球经济呈现低增长、高黏性通胀、地缘风险主导的复杂态势,全球增长预期被多次下调,主要经济体政策在“抗通胀”与“稳增长”间艰难平衡;我国经济积极应对外部挑战,克服内部困难,生产供给平稳增长,新动能加快成长,国民经济延续总体平稳、向新向优的发展态势。我国产业用纺织品行业运行整体平稳,工业增加值保持中速增长。