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关键词： Class activation map (CAM)   Multi-label tasks   Gradient-based visualization   Model interpretability  

摘要：

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  Propose a novel class activation map algorithm to reduce inter-class interference in multi-label tasks.
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  Introduce multi-label gradient feedback to suppress gradient noise from adjacent object categories.
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  Design a recursive fusion of middle layer saliency maps module to integrate fine-grained information for precise localization.

关键词： Coronary artery disease   hospital length of stay   feature selection   bayesian optimisation   explainable AI  

摘要： Coronary Artery Disease (CAD) remains one of the leading causes of mortality worldwide and accounts for a great number of prolonged hospital stays, which increase the cost of healthcare and its resource consumption. This research presents Graph Neuro Boost, a new method of predicting hospital LOS for CAD patients based on hybrid feature selection and classification, and characterized by high accuracy of prediction. Using the MIMIC-III dataset, the method involves complete data preparation, analysis, and preprocessing. A Graph Neuro Feature Selector was built by combining the autoencoder-based embedded method and the filter method using graph theory and Kruskal's algorithm. The method efficiently identified 16 critical features in just 2.68 seconds, surpassing traditional hybrid feature selection approaches. Those features were then optimized using Bayesian optimization together with XGBoost, implementing a balanced Expected Improvement and Upper Confidence Bound technique to reduce log loss. Graph Neuro Boost resulted in an accuracy of 98.57%. In addition to superior accuracy, Graph Neuro Boost demonstrated outstanding performance relative to baseline models on multiple evaluation metrics. The SHAP analysis was also employed to interpret feature contributions, improving model transparency and supporting clinical decision-making, patient management, and efficient healthcare resource allocation.

关键词： GSRCA   Interpretability analysis   Raman spectroscopy classification   Spectral region contribution quantification  

摘要： To address the fragmented point-wise gradients and limited physical interpretability of standard Grad-CAM in spectral analysis, this study proposes GSRCA (Grad-CAM-based Spectral Region and Contribution Analysis). Its core innovation lies in an adaptive region segmentation strategy that aggregates fragmented gradient points into continuous intervals corresponding to molecular vibrational modes. Based on a CNN framework, GSRCA first computes class-specific gradients via Grad-CAM, then employs a weight-distribution-based adaptive region segmentation strategy to aggregate discrete gradient responses into physically meaningful continuous spectral regions. Finally, the relative contribution of each region to the classification result is quantified through gradient integration and expressed as a percentage.On a Raman spectroscopy dataset containing six categories of illicit drugs, the key regions identified by GSRCA are generally consistent with characteristic vibrational bands reported in the literature, and region deletion/insertion tests further validate the effectiveness of the proposed contribution quantification scheme. Compared with conventional Grad-CAM, LIME, and SHAP-based methods such as GRASS, GSRCA shows better performance in regional integrity, physical interpretability, and computational efficiency. Experiments also show that the method requires no architecture-specific parameter tuning and can be transferred to dilated CNNs, Transformers, and remote sensing hyperspectral data, demonstrating model compatibility and generalization capability. GSRCA provides a physically interpretable and versatile explanation method for spectral classification models.

关键词： 3D printing   Biomechanics   CAD   Finite element analysis (FEA)   Parametric model   Simulation  

摘要： Purpose

关键词： Cancer survivorship   Complementary and alternative medicine   Chinese immigrants   Information practices   Information encountering   Trust   Credibility   Cognitive authority   Fractured information landscapes  

摘要： Purpose

关键词： Accuracy analysis   CAD-CAM   Custom post-and-core   Dental impression technique   Digital scanning   Distortion  

摘要： To compare the accuracy of different acquisition strategies for CAD-CAM post-and-core restorations in molars with dual post spaces and to explore the underlying technique-specific error mechanisms.

关键词： AA   Average Amplitude   ACE   A Compact ENDF   ANL   Argonne National Laboratory (USA)   API   Application Programming Interface   BP   Burnable Poison   CAD   Computer-Aided Design   CR   Control Rod   CRP   Coordinated Research Project   CSG   Constructive Solid Geometry   DNBR   Departure from Nucleate Boiling Ratio   ENDF   Evaluated Nuclear Data File   ENSIA   National School of Artificial Intelligence (Acronym in French)   FA   Fuel Assembly   FFTBM   Fast Fourier Transform-Based Method   HDF5   Hierarchical Data Format, version 5   IAEA   International Atomic Energy Agency   MCTHC   Monte-Carlo Thermal-Hydraulic Coupling scheme   MTR   Material Testing Reactor   NJOY   Nuclear Data Processing System for ENDF   N-TH   Neutronic‒Thermal-Hydraulic   OFIR   Onset of Flow Instability Ratio   ONBR   Onset of Nucleate Boiling Ratio   OPAL   Open Pool Australian Light water reactor   OpenMC   Open-source Monte Carlo   PARET   Program for the Analysis of Reactor Transients   PLTEMP   PLate TEMPerature   RCMS   Reactor Control and Monitoring System   RELAP   Reactor Excursion and Leak Analysis Program   RIA   Reactivity Initiated Accident   RR   Research Reactor   V&V   Verification and Validation   WF   Weighted Frequency   WR   Wide-Range   Neutronic–thermal–hydraulic (N/TH) coupling   Reactivity initiated accident (RIA)   Monte Carlo methods   OPAL research reactor   Subchannel and System thermal–hydraulic codes  

摘要：

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  Development of a MC–based two-step neutronic–thermal–hydraulic coupling scheme for OPAL steady-state and transient analyses.
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  Verification of hotspot location and power redistribution under different control-rod movements using coupled OpenMC calculations.
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  Comparison of MC coupling calculations, RELAP5, PARET, standalone and experimental results for an RIA scenario.
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  Introduction of an FFT-Based Method to complement time-domain analyses and quantify transient signal agreement.
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  Assessment of Monte Carlo-based coupling, system and subchannel codes, for reproducing key RIA physical phenomena.

关键词： Coronary artery disease   FV   Monocyte   Residual inflammation   Tissue factor  

摘要： The underlying proinflammatory mechanism of coagulation factor VⅡ in coronary artery disease (CAD) remains unclear. According to the inclusion criteria, 24 non-CAD subjects and 24 patients with CAD were enrolled. The expression levels of pro-inflammatory (CD14⁺CD86⁺, CD14⁺CD163^-), anti-inflammatory monocytes (CD14⁺CD163⁺), CD14⁺CD142⁺ and CD14⁺PAR2⁺ monocytes in peripheral blood were detected by flow cytometry. The levels of TNF-α, IL-1β, IL-6, IL-10, and FVⅡ in plasma were determined by ELISA. In vitro experiments were conducted to induce inflammatory THP-1 by FVⅡa. The FVⅡa/TF complex inhibitor PCI-27,483 and PAR2 antagonist AZ3451 were used to clarify the mechanisms. Compared with the control group, the percentage of CD14⁺CD86⁺ pro-inflammatory monocytes were significantly increased in the CAD group, and further elevated after PCI. The results of the levels of CD14⁺CD142⁺ and CD14⁺PAR2⁺ monocytes showed the same trends with CD14⁺CD86⁺ pro-inflammatory monocytes. The levels of CD14⁺CD163⁺ anti-inflammatory monocytes and IL-10 were decreased in CAD patients, but increased after PCI. The pro-inflammatory factors and FVⅡ were significantly elevated in the CAD group and significantly decreased after PCI. Correlation analysis revealed that FVⅡ, TF, and PAR2 were significantly associated with CD14⁺CD86⁺ pro-inflammatory monocytes, and inflammatory factors. In vitro studies further confirmed that the FVⅡa/TF coagulation complex and PAR2 could activate NF-κB in monocytes and aggravate inflammation. Our findings suggest that crosstalk between monocytes and the coagulation complex might contribute to residual inflammation in CAD, potentially involving the FVIIa/TF/PAR2-NF-κB signaling pathway. Based on these observations, we hypothesize

关键词： Cardiovascular disease   Drug-eluting balloons   Smart balloon   Responsiveness   ANP   3-Amino-3–2-nitrophenyl propionic acid   AS   Atherosclerosis   BMS   Bare metal stents   BP   Black phosphorus   BRS   Biodegradable stents   CA   Caffeic acid   CAD   Coronary artery disease   c-MCT-3   caged Histone deacetylase inhibitor   CVD   Cy5   Cyanine 5   DEB   Drug-eluting balloons also referred to as DCB   DES   Drug-eluting stents   DHE   Dihydroethidium   EC   Endothelial cells   FDA   Food and Drug Administration   GP   G4-RRHH   GWS   Guidewire shadow   HBA   Hydroxymethylphenylboronic acid   H&E   Hematoxylin and eosin   IL-1β   Interleukin-1#amp   IL-6   Interleukin-6   iNOS   Inducible nitric oxide synthase   ISR   In-stent restenosis   LA   Lauric acid   Latex   Latex beads   M-Arg   Arginine-derived monomers   miR126   MicroRNA-126   MJAMS/PTX/aV   Platelet-derived nanomotor-coated balloons   MN   Microneedle   MNB   MN balloon   MNBC   MN balloon catheter   MNDEB   MN drug-eluting balloons   MNDLB   MN drug-balloon   NIR   Near-infrared   NO   Nitric oxide   PAD   Peripheral arterial disease   G4   Polyamidoamine polymer generation 4   PBC   ROS-responsive polyglutamic acid prodrug modified with 4-hydroxymethylphenylboronic acid and caffeic acid   PC   Photo-cleavable   PCB   Paclitaxel-coated balloon   PDMS   Polydimethylsiloxane   PM   Paclitaxel microcapsules   PMA   PolyN-methylmethacrylate-arginine   PMCB   PM-coated balloon   PML   PolyN-methylmethacrylate-lysine   Pt   Platinum   PTCA   Percutaneous transluminal coronary angioplasty   PTX   Paclitaxel   ROS   Reactive oxygen species   SVD   Small vessel disease   TNF-α   Tumor necrosis factor-#amp   TPP   Triphenylphosphine   US   Ultrasound   UV   Ultraviolet   VSMC   Vascular smooth muscle cells  

摘要：

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  The clinical status and key challenges of DCB in cardiovascular disease management are systematically reviewed.
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  Recent advances, current status, inherent limitations, and development trends of smart DCB are comprehensively summarized.
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  The advantages and disadvantages of smart DCB versus conventional DCB are compared, and their clinical translation potential is analyzed.
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  Endogenous and exogenous stimuli for smart DCB are classified and summarized, guiding the design of next-generation intelligent balloon drug delivery systems.
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  Future research directions and clinical application prospects of smart DCB are systematically outlined.

关键词： Vestibuloplasty   Dental implants   CAD-CAM   Jaw reconstruction  

摘要： Implant-supported rehabilitation following maxillary or mandibular reconstruction with vascularized osseous free flaps is frequently compromised by inadequate peri‑implant soft tissues, vestibular obliteration, and scar contracture. This study describes a fully digital workflow for peri‑implant soft tissue management based on a patient-specific CAD/CAM vestibuloplasty stent (PSVS) and reports its preliminary clinical use.