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关键词： Critical doping threshold   Discontinuous   Gd2(Zr1−xCex)2O7 ceramics   Zirconate-cerate transformation  

摘要： Rare-earth zirconate-based thermal barrier ceramic materials, such as Gd₂Zr₂O₇, exhibit low thermal conductivity and excellent high-temperature stability, but both their coefficient of thermal expansion (CTE) and thermal conductivity can be further optimized. In this work, Gd₂(Zr_1−xCe_x)₂O₇ (x = 0–1.0) ceramics were synthesized via a solid-state reaction to simultaneously optimize both properties. However, a critical transition from zirconate to cerate dominance was identified at x = 0.5, leading to discontinuous changes in thermophysical properties. After x = 0.5, the CTE increases sharply, reaching a maximum of 12.85 × 10⁻⁶ K⁻¹ at x = 1.0. Thermal conductivity decreases when x < 0.5 and increases when x > 0.5; the sample with x = 0.4 exhibits the minimum thermal conductivity of 1.45 W m⁻¹ K⁻¹ at 1100 °C, which is 22% lower than that of Gd₂Zr₂O₇. Ce⁴⁺ doping at the B-site enables synergistic optimization of low thermal conductivity and high CTE, providing a promising route for designing high-performance thermal barrier ceramic materials.

关键词： Anti-PD-1 therapy   Biomarker   Head and neck squamous cell carcinoma   Immune checkpoint blockade   PARD6G   Tumor microenvironment  

摘要： Head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy with limited response to immune checkpoint blockade (ICB) therapies. Identifying reliable biomarkers to predict ICB response is critical for improving clinical outcomes. In this study, we identified PARD6G as a key gene associated with response to anti-PD-1 therapy in HNSCC through integrative analysis of single-cell and bulk transcriptomic data from pre- and post-treatment cohorts. Virtual PARD6G knockout modeling revealed that low PARD6G expression was associated with increased overall immune cell infiltration but significantly reduced infiltration of functional T cells. In vitro, PARD6G overexpression suppressed HNSCC cell proliferation and cell-cycle progression, while its knockdown promoted tumor growth. In vivo, PARD6G-deficient tumors exhibited accelerated growth and resistance to anti-PD-1 treatment, accompanied by a reshaped immune landscape favoring immunosuppression. In conclusion, this study establishes PARD6G as a novel predictive biomarker for anti-PD-1 efficacy and a functional tumor suppressor in HNSCC. Its loss mediates ICB resistance by reshaping the immune microenvironment, providing new insights into the mechanisms of ICB resistance in HNSCC and suggesting potential therapeutic targets.

关键词： Insulin sensitivity   Transforming growth factor beta 1 (TGFβ1)   Insulin receptor substrate 1 (IRS1)   Cullin 7 (CUL7)  

摘要： Obesity is associated with insulin resistance, a major risk factor for type 2 diabetes (T2D), yet the underlying mechanisms remain incompletely defined. We hypothesized that elevated transforming growth factor beta 1 (TGFβ1) level is associated with impaired insulin sensitivity.

摘要： Sequestosome-1 (SQSTM1/p62) is a multifunctional scaffold protein that links autophagy, proteasomal degradation, and redox signalling, but its mitochondrial functions in lower eukaryotes remains unclear. Using p62 mutant strains of the protist, Dictyostelium discoideum, we demonstrate that p62 is a critical regulator of mitochondrial integrity and oxidative stress tolerance. Loss of p62 reduced cell survival during starvation and elevated oxidative stress, as evidenced by the increased proportion of DHE-positive cells, enhanced MitoSOX fluorescence, and nearly 40% reduction in mitochondrial membrane potential. Mitochondrial network analysis revealed a fragmented mitochondrial architecture in p62⁻ cells, consistent with a fission-dominated dynamics as quantified by live-cell time-lapse confocal microscopy. Overexpression of p62, restored redox balance, upregulated antioxidant enzyme activities (SOD and GST), and shifted mitochondrial dynamics towards fusion, resulting in mitochondrial elongation and network formation. Notably, p62⁻ cells were also characterised by increased basal and starvation-induced mitophagy that persisted despite canonical autophagy modulation, suggesting the involvement of a non-canonical, Atg8-independent mechanism. Collectively, these findings reveal a conserved role for p62 in governing mitochondrial quality control by modulating redox homeostasis and mitochondrial dynamics.

关键词： Core-shell structure   TS-1 zeolite   S-1 zeolite   Cobalt oxide   Ethylbenzene oxidation   Acetophenone  

摘要：

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  The core-shell structure CoOx/TS-1@S-1 was synthesized via a hydrothermal method.
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  The catalyst demonstrates excellent cycling stability and regeneration performance in the oxidation of ethylbenzene to acetophenone.
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  Reaction involves dual-path synergistic mechanism of radicals and carbocations.
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  Optimized conditions achieve 84.5% ethylbenzene conversion and 79.8% acetophenone.

关键词： Mammuthus primigenius   Late Gravettian   South-eastern Germany   Bavaria   Cut marks   Bones  

摘要：

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  Mammoth skeleton from SE Germany (26.9–25.3 ka cal BP) bears cut marks.
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  Few indications of human presence in Bavaria exist for this period.
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  Final Gravettian excursions into Bavaria before the LGM-related hiatus.

关键词： Electrodeposition   Ternery chalcogenides   CO2 reduction   Photoelectrochemical properties  

摘要：

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  Novel CdSSe films via room-temperature electrodeposition on nickel.
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  Comprehensive film characterization using XRD, EDX, and SEM.
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  Promising photoelectrochemical performance for CO₂ reduction.
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  Electronic properties analyzed with Mott-Schottky and impedance studies.

关键词： Alcoholic fatty liver disease   IGF-1   PPARG   Rosavin   p38 MAPK  

摘要：

摘要： Sepsis-induced acute lung injury (ALI) and early fibrotic remodeling remain major clinical challenges with limited effective treatments. In this study, we systematically investigated the role of fibroblasts in sepsis-associated lung injury and fibrosis using single-cell RNA sequencing combined with functional validation. We found that fibroblast states shifted from a resting state toward pro-inflammatory and pro-fibrotic phenotypes during sepsis, including Glycoprotein-producing Fibroblasts, Stress-activated Fibroblasts, and Inflammatory Fibroblasts, accompanied by increased IL-6 signaling activity. Mechanistically, IL-6/Signal Transducer and Activator of Transcription 3 (STAT3) signaling was associated with impaired mitochondrial oxidative phosphorylation (OXPHOS) in fibroblasts, increased mitochondrial ROS production, and increased activation of the AP-1 transcription factor family, which was linked to enhanced profibrotic protein expression. Pharmacological intervention with clinically relevant glucocorticoids, dexamethasone and methylprednisolone, attenuated lung injury and fibrosis in experimental sepsis-associated lung injury and was associated with suppression of the IL-6/STAT3/OXPHOS/AP-1 axis. Collectively, these findings highlight IL-6/STAT3-mediated mitochondrial metabolic remodeling in fibroblasts as a potential therapeutic target for sepsis-induced lung injury and fibrosis.

关键词： sup>28SiH4   Absolute line strengths   Dipole moment parameters   Hot bands  

摘要： Absolute line strengths of ²⁸SiH${}_4$ were measured for the first time with a Bruker Fourier transform infrared spectrometer IFS120HR and analyzed in the 1180–1360 cm⁻¹ region where the ${\nu }_1-{\nu }_4$, ${\nu }_3-{\nu }_4$, ${\nu }_3-{\nu }_2$ and ${\nu }_1-{\nu }_2$ ”hot“ bands of SiH${}_4$ are located. The strengths of 429 isolated nonsaturated and not too weak (i.e., which transmittances for the present experiment are