课程文献中心 更多>>

关键词： HTLV   STLV   Africa   molecular epidemiology   accessory proteins  

摘要： Central Africa is the largest region of human T-cell Leukaemia virus (HTLV-1) endemicity with several million people estimated to be infected. Based on the study of the LTR region, it is also the region with the highest HTLV-1 diversity, with the presence of genotypes a-b and d-g. However, complete genomic sequences are still lacking for Central African genotypes. Here, we report the first large collection of complete HTLV-1 sequences for genotypes b, d and f from Central Africa and neighbouring countries. We identified substantial diversity within the HTLV-1b genotype, including a newly defined clade that we designated HTLV-1b-del. It mainly comprises strains from the Democratic Republic of the Congo (COD) and neighbouring countries and is characterized by a distinctive 12-bp-long deletion. We also generated the complete sequence of the STLV-1 strain from Allenopithecus nigroviridis from the COD. This strain belongs to the PTLV-1b genotype and carries a 12-bp duplication in the pX region. Lastly, we found that, except for HTLV-1a strains, HTLV-1 genomes generally lack open reading frames encoding the canonical accessory protein P12;instead, they encode either shorter versions of the protein or an ORF lacking a start ATG codon. This work substantially expands the genomic landscape of HTLV-1 in Central Africa and provides a critical resource for understanding viral diversity.

关键词： Sentinel-1   Sentinel-2   post-earthquake recovery monitoring   backscatter coefficients   Noto Peninsula earthquake   time-series analysis  

摘要： Sentinel-1 and Sentinel-2 have been widely used for earthquake damage detection;however, their use in monitoring long-term recovery activities remains largely unexplored. This study evaluates the effectiveness of Sentinel-1 and Sentinel-2 satellite observations for monitoring post-earthquake recovery processes. Focusing on the 2024 Noto Peninsula earthquake, indices were used to assess the detectability of surface changes associated with two key recovery activities: debris removal and temporary housing construction. A detailed analysis of the long-term Sentinel-1 backscatter time-series monitoring was conducted. Public demolition sites exhibited characteristic temporal changes in the vertical transmit-horizontal receive polarization: an initial increase associated with debris generation, followed by a gradual decrease, and then a sharp decline corresponding to the commencement of demolition. At the temporary housing construction sites, the vertical transmit-vertical receive polarization values increased rapidly during construction and remained elevated. The findings revealed that different recovery activities produce distinct backscatter signatures, suggesting that synthetic aperture radar time-series analysis can serve as an effective tool for characterizing post-disaster recovery. Applying these temporal patterns across wider areas enables the identification of collapsed structures and newly constructed temporary housing. This study demonstrated the potential of freely available satellite data to systematically monitor reconstruction processes.

关键词： AKI   IL-18   KIM-1   FGF-23   paracentesis  

摘要： Acute kidney injury (AKI) is a potentially fatal complication in patients with decompensated cirrhosis having therapeutic paracentesis, and early diagnosis is still difficult because of the low sensitivity of serum creatinine. We preemptively tested serum interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), and fibroblast growth factor-23 (FGF-23) in early prediction of post-paracentesis AKI in 80 hospitalized patients with tense ascites and normal baseline kidney function. Samples of blood were collected 2 h pre-paracentesis and 24 h post-paracentesis. Based on the Kidney Disease: Improving Global Outcomes definition, AKI, which happened within 72 h, was present in 40% of patients. Biomarkers levels at baseline were comparable. In 24 h of paracentesis, IL-18, KIM-1, and FGF-23 were high in patients who later developed AKI (all p value below .001) and had high-absolute changes than the non-AKI group. The largest discriminative performance was observed of FGF-23 (area under the curve 0.959), then IL-18 (0.931), and KIM-1 (0.903). In multivariate logistic regression controlling MELD-Na score, serum albumin, baseline eGFR and ascitic fluid volume, the post-paracentesis FGF-23 was still independently connected with AKI. Biomarkers of tubular injury, especially FGF-23, which increased shortly after the procedure were strongly correlated with future AKI and could increase risk stratification pending external validation.

关键词： NSCLC   IL-1 beta   chemotherapy   immunotherapy  

摘要： Interleukin (IL)-1 beta is known to promote lung cancer growth in both humans and mice. However, in the context of the current standard of care, which includes chemotherapy and immune checkpoint inhibitors, IL-1 beta can overcome resistance.

关键词： Spaceborne GNSS-R   TM-1 constellation   ocean wind speed retrieval   machine learning   multi-polarisation mode fusion  

摘要： Wind Speed (WS) is essential for air-sea interaction studies and weather monitoring. Spaceborne GNSS-R shows strong potential for WS retrieval, yet accuracy under high-wind conditions and environmental coupling remain challenging. This study employs China's multi-constellation GNSS-R mission Tianmu-1 (TM-1), integrating BDS, GPS, GLONASS, and Galileo observations. Bayesian-optimized machine learning models (CatBoost, LightGBM, and XGBoost) were developed by incorporating environmental variables, including significant wave height, sea surface temperature, and total precipitation. Three fusion strategies-multi-GNSS, multi-polarization, and pure data fusion-were evaluated over the Yellow and Bohai Seas. Results show that environmental integration reduces RMSE by 20 similar to 25% and increases correlation by 0.1 similar to 0.2. High-wind sample weighting effectively alleviates performance degradation under high conditions. LHCP observations from the C and E systems perform best, with accuracy ranked as C > E > G > R. Among fusion schemes, multi-polarization fusion achieves the highest accuracy (R = 0.88, RMSE = 1.685 m/s) and best spatial consistency. Overall, the proposed strategy significantly enhances the accuracy and robustness of GNSS-R WS retrieval and provides an effective framework for future multi-constellation missions and operational applications.

关键词： Endothelin-1   carotid-femoral pulse wave velocity   aortic stiffness   chronic kidney disease  

摘要： Increased aortic stiffness (AS) is a recognized predictor of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD), and endothelin-1 (ET-1), a potent vasoconstrictor, has been associated with vascular dysfunction and atherosclerosis. This study examined the relationship between serum ET-1 levels and AS in patients with non-dialysis CKD. A total of 232 adults with CKD stages 3-5 were enrolled. Fasting blood samples were obtained to measure serum ET-1 concentrations using an enzyme immunoassay, and AS was assessed by carotid-femoral pulse wave velocity (cfPWV) measured using cuff-based volumetric displacement, with cfPWV >10 m/s defining AS. Among the participants, 75 patients (32.3%) were classified as having AS. Compared with those without AS, patients with AS were older and had higher prevalences of diabetes mellitus and hypertension, as well as significantly higher serum ET-1 levels, blood pressure, fasting glucose, HbA1c, and urine protein-to-creatinine ratio. Serum ET-1 levels were positively correlated with cfPWV and remained independently associated with cfPWV in multivariable linear regression analysis. Furthermore, multivariable logistic regression identified serum ET-1, age, diastolic blood pressure, and diabetes mellitus as independent factors associated with AS, with consistent results observed in bootstrap analyses. These findings demonstrate an independent association between serum ET-1 levels and increased cfPWV and AS in patients with non-dialysis CKD.

关键词： Sepsis associated acute kidney injury   endothelial glycocalyx   renal resistive index   bedside doppler ultrasound   macro- microcirculatory dysfunction  

摘要： The interplay between macro-microcirculatory dysfunction and sepsis associated acute kidney injury (SA-AKI) remains elusive. This study aimed to explore the association between hemodynamics and endothelial damage in SA-AKI by evaluating the combined predictive value of renal resistive index (RRI) and plasma syndecan-1. This prospective observational study enrolled 80 septic patients admitted to the general intensive care unit (ICU) of a tertiary hospital from May to December 2024. Plasma syndecan-1 levels were measured at admission, and RRI was assessed within 24 h of ICU admission. Univariate and multivariate logistic regression models were applied to identify independent risk factors of SA-AKI. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis by calculating the area under the curve (AUC). Among 80 septic patients, 41(51.25%) developed AKI. Syndecan-1 levels were significantly higher in the AKI group [109.95 (73.67-221.40) vs.73.67 (54.59-109.95) ng/mL, p = 0.007], and RRI values were markedly elevated (0.69 +/- 0.08 vs. 0.60 +/- 0.06, p < 0.001) compared to non-AKI patients. Univariate analysis revealed syndecan-1 (OR = 2.68, 95%CI 1.29-5.59) and RRI (OR = 1.18, 95%CI 1.09-1.28) as predictors of AKI. In multivariate models adjusted for confounders, both plasma syndecan-1 (OR = 3.57, 95%CI 1.01-12.64, p = 0.048) and RRI (OR = 1.19, 95% CI 1.07-1.33, p = 0.002) retained significance. A predictive model using a combination of plasma syndecan-1 and RRI achieved superior diagnostic performance (AUC 0.859, sensitivity 87.8%, specificity 92.3%). In patients with SA-AKI, elevated plasma syndecan-1 and RRI were identified as independent risk factors. The combination of syndecan-1 and RRI can serve as synergistic biomarkers for the prediction of SA-AKI.

关键词： Bifurcations   Khater method   strange attractors   return maps   phaseportraits  

摘要： Soliton solutions and chaotic analysis in integrable equations have become a hot topic in recent years. This work presents the qualitative dynamics and analytical solutions of (4+1)-D Boiti-Leon-Manna-Pempinelli (BLMP) model. Utlizing dynamical system approach, the mathematical analysis is performed. The given model is transformed into system of nonlinear ordinary differential equations (ODEs) via the Galilean transform. We study the bifurcations, quasi-periodic and chaotic dynamics, return maps, power spectrum, and strange attractors of the proposed model. Moreover, the soliton solutions are obtained with applications of the Khater method and the modified extended Tanh-function method (METM). The obtained results are illustrated in detail through 2D and 3D graphical representations.