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关键词： Co-precipitation   Copper-doped materials   Cu-doped ferrites   Lithium-ion batteries   Oxygen vacancies   Spinel ferrite  

摘要： Cu-doped Co–ferrite composites (Cu_xCo_1-xFe₂O₄, x = 0.1, 0.2, and 0.3) are successfully synthesized via a simple co-precipitation method and evaluated as anode materials for lithium-ion batteries (LIBs). Among the prepared samples, the composite with x = 0.2 demonstrates the best electrochemical performance, delivering a high reversible capacity of 784 mAh g⁻¹ at a current density of 100 mA g⁻¹ after 100 charge–discharge cycles. By contrast, the capacities of the x = 0.1 and x = 0.3 composites decline significantly after 60 cycles. Comprehensive material characterizations reveal that the superior performance of the Cu_0.2Co_0.8Fe₂O₄ composite can be attributed to its optimal phase composition, enhanced nanoparticle interconnectivity, and the presence of abundant oxygen vacancies, which collectively improve the electronic conductivity. The results underscore the importance of the spinel structure, the Cu-to-Co ratio, and the resulting microstructural features in achieving a high surface area conducive to efficient ion transport. This work not only highlights the potential of Cu-doped Co–ferrites as high-performance LIB anodes but also introduces a straightforward and scalable chemical synthesis route for their fabrication.

关键词： 成人   节段性膜性肾病   膜性肾病  

摘要： 节段性膜性肾病(segmental membranous nephropathy, sMN)是儿童好发的一种特殊类型的肾脏疾病,通常表现为肾小球基底膜外侧、上皮下免疫复合物节段性分布,而非全肾受累。sMN并不表现为典型肾病综合征,通常PLA2R、THSD7A阴性,常合并其他肾脏疾病,临床诊断需首先排除继发性因素。现报道1例成人节段性膜性肾病病例。1 病例介绍患者男,20岁,主因“体检发现蛋白尿20余天”入院。

关键词： Non-destructive testing   Power engineering steels   Eddy current   Coil impedance  

摘要： Ferritic–martensitic P91 steel is widely used in high-temperature power plant components due to its excellent creep resistance and mechanical stability. However, long-term service exposure and improper heat treatment can lead to progressive microstructural degradation, resulting in a reduction of mechanical properties and component lifetime. Reliable, non-destructive methods capable of detecting such microstructural changes are therefore essential for condition monitoring and life assessment. In this study, the influence of controlled heat treatment at temperatures ranging from 200 °C to 600 °C on the eddy current (EC) response of P91 steel was investigated. Eddy current measurements were performed over a range of probe operating frequencies, and changes in resistance and reactance components were quantitatively analyzed. The EC results were correlated with detailed microstructural observations, revealing a strong relationship between electromagnetic response and recovery and tempering phenomena, including dislocation density reduction, martensite lath degradation, and carbide coarsening. The findings demonstrate that eddy current testing is highly sensitive to thermally induced microstructural evolution in P91 steel and shows significant potential as a non-destructive tool for assessing thermal exposure and material degradation in power plant components.

关键词： Solubility   Amino acid   Ionic liquid   NRTL  

摘要： A comprehensive understanding of the solubility of amino acids across different solvents and environmental conditions enables improved extraction and purification strategies, also providing insight into molecular interactions and supporting the development of more accurate modelling approaches. In this work, the solubility of seven collagen-forming amino acids (glycine, β-alanine, l-proline, trans-4‑hydroxy-l-proline, l-glutamic acid, l-aspartic acid and l-arginine) in the ionic liquid 1-ethyl-3-methylimidazolium propionate, and its mixture with water at equal mass proportions, was measured at temperatures ranging from 298.15 K to 328.15 K and atmospheric pressure. Compositions were determined from density–composition calibration curves. Acidic amino acids showed the highest solubility in the pure ionic liquid, followed by proline and trans-4‑hydroxy-l-proline, key amino acids for collagen stabilization. Using water as a co-solvent increased the solubility on a mass basis of l-proline and β-alanine but decreased that of the other amino acids. Solubility increased with temperature across all systems. A comparison with other imidazolium salts suggests that increasing the ionic liquid’s hydrophobicity, whether by elongating the alkyl chain of the anion or cation, leads to a decrease in solubility. The van’t Hoff equation was found to accurately describe solubility across the studied temperature range and was used to calculate apparent thermodynamic properties of dissolution. All the apparent properties were found to be positive, indicating and endothermic and entropy-favoured process. Finally, the experimental data were correlated using the Non-Random Two-Liquid (NRTL) model.

关键词： Gastric cancer   Migration and infiltration   SPIN1   Slug   Claudin-1  

摘要： Metastases are responsible for over 90% of the deaths in patients with gastric cancer (GC). Our previous study revealed that SPIN1 promotes the invasion and metastasis of GC; however, the underlying mechanism remains unclear.

关键词： Methamphetamine addiction   Microglial activation   Neuroinflammation   Minocycline   Cognitive impairment  

摘要：

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  Methamphetamine exposure induces anxiety-related behavioral alterations and cognitive impairments beyond reward-related effects.
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  Pharmacological inhibition of microglial activation with minocycline is associated with attenuation of METH-induced CPP and behavioral alterations.
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  METH addiction is associated with activation of hippocampal NF-κB/NLRP3/Caspase-1 signaling.

关键词： Eye-safe wavelength   High power fiber laser   Laser oscillator   Tm fiber laser  

摘要： We report a continuous-wave thulium (Tm)-doped fiber laser oscillator with >1 kW output power operating at 1940 nm under the optimized cooling condition. Using a water calorimetry method, the temperature increases and its impact on output power were experimentally investigated, confirming good agreement with theoretical predictions. To mitigate thermal effects on laser performance, a bi-directional pumping configuration was implemented, theoretically reducing the maximum Tm fiber temperature by ∼40% compared to forward pumping. Under the optimized cooling condition, the Tm fiber laser yielded a maximum output power of 1032 W for an incident pump power of 1785 W, corresponding to a slope efficiency of 58.5%. A near-diffraction-limited beam quality was maintained at all power levels, along with excellent output stability.

关键词： ESCRT pathway   HIV-1 budding   Membrane scission   Viral assembly sites   Ubiquitination   Vps4 ATPase   ALIX   Alg-2 Interacting Protein X   AMSH   Associated Molecule with the SH3 Domain of STAM   BST-2   Bone Marrow Stromal antigen 2   CCL2   C-C Motif Chemokine Ligand 2   CEP55   Centrosomal Protein of 55 kDa   CHMP   Charged Multivesicular body Protein   DUB   DeUbiquitinating Enzyme   ESCRT   Endosomal Sorting Complexes Required for Transport   Gag   Group-specific antigen   HECT   Homologous to the E6-AP Carboxyl Terminus   HIV-1   Human Immunodeficiency Virus Type 1   IP₃R   Inositol 1,4,5-trisphosphate Receptor   IPMC   Intracellular Plasma Membrane-Connected Compartment   ISG   Interferon-Stimulated Gene   ISG15   Interferon-Stimulated Gene 15   L domain   Late domain   MA   Matrix domain   MICAL1   Molecule Interacting with CasL 1   MIT   Microtubule Interacting and Trafficking domain   MVB   MultiVesicular Body   NC   NucleoCapsid domain   Nedd4   Neural precursor cell Expressed, Developmentally Down-regulated 4   PALM   Photoactivated Localization Microscopy   PI(4,5)P   Phosphatidylinositol 4,5-bisphosphate   PLC   PhosphoLipase C   PTAP   Pro-Thr-Ala-Pro   PTM   Post-Translational Modification   STED   Stimulated Emission Depletion microscopy   STORM   Stochastic Optical Reconstruction Microscopy   SUMO   Small Ubiquitin-like Modifier   TBK1   TANK-Binding Kinase 1   TEM   Tetraspanin-Enriched Microdomain   Tsg101   Tumour susceptibility gene 101   VCC   Virus-Containing Compartment   Vps   Vacuolar protein sorting   Vpu   Viral protein U   Vpr   Viral protein R   YPXₙL   Tyr-Pro-Xₙ-Leu  

摘要：

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  HIV-1 exploits ESCRT via dynamic, regulated host–virus interplay.
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  Nanoscale organization defines ESCRT recruitment and scission efficiency.
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  PTMs and conformational switches gate ESCRT activation during budding.
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  Redundant ESCRT recruitment pathways enable viral adaptability.
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  ESCRT-III/Vps4 identified as convergent targets for antiviral strategies

摘要： A design is called t-pyramidal when it has an automorphism group which fixes t points and acts sharply transitively on the remaining points. We determine all symmetric $(2^k-1,2^{k-1},2^{k-2})$-designs which are $(2^{k-1}-1)$-pyramidal over abelian groups.

关键词： Monoclonal antibody   N protein   PRRSV   PRRSV-1 infection   Peptide ELISA  

摘要： Porcine reproductive and respiratory syndrome virus (PRRSV) are responsible for reproductive failure in sows and respiratory diseases in pigs, inflicting significant economic losses worldwide. Due to continuous mutation and recombination, PRRSV exhibit remarkable genetic diversity, necessitating detection methods capable of recognizing PRRSV-2 and/or PRRSV-1 strains. In this study, four monoclonal antibodies (mAbs) targeting the PRRSV-1 nucleocapsid (N) protein were generated, and the precise and novel linear B-cell epitopes were identified as ⁵⁴PHFPL⁵⁸, ⁵³KPHFP⁵⁷, and ⁵⁹AAEDDIRHH⁶⁷, respectively. The epitopes ⁵⁴PHFPL⁵⁸ and ⁵³KPHFP⁵⁷ are highly conserved across all major PRRSV-2 lineages and PRRSV-1 subtypes, whereas the epitope ⁵⁹AAEDDIRHH⁶⁷ is relatively conserved only in PRRSV-1. Correspondingly, the PRRSV-1 specific mAb 6B4 showed reaction only with PRRSV-1 strains, but not with PRRSV-2 strains. The 6B4 peptide-based ELISA was developed for the detection of PRRSV-1 antibody, which showed an agreement rate of 83.6% with commercial PRRSV Ab ELISA kit in testing 55 clinical samples, indicating the potential of this peptide-based ELISA for preliminary application.