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关键词： Mcl-1 inhibitors   Sulfonimide scaffold   Venetoclax-resistant   Antitumor activity   Drug-likeness optimization   Mcl-1   Myeloid cell leukemia 1   Molm-13_VenR   Venetoclax-resistant Molm-13 cells   MM   multiple myeloma   CML   chronic myeloid leukemia   ALL   acute lymphoblastic leukemia   AML   acute myeloid leukemia   FP   fluorescence polarization   SAR   structure-activity relationship   PIDA   (diacetoxyiodo)benzene   DCM   dichloromethane   MeOH   methanol   rt   room temperature   NaOH   sodium hydroxide   TEA   triethylamine   Cs2CO3   cesium carbonate   CTL assay   CellTiter-Lumi™ Luminescent Cell Viability assay   ITC   Isothermal titration calorimetry   BLI   biolayer interferometry   Co-IP   Co-immunoprecipitation   PARP   poly ADP-ribose polymerase   WB   western blot   PAMPA   parallel artificial membrane permeability assay   SIF   simulated intestinal fluid   SGF   simulated gastric fluid   PK   pharmacokinetic   SD rats   Sprague–Dawley rats   HR-MDS   high-risk myelodysplastic syndromes  

摘要：

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  A series of novel Mcl-1 inhibitors were designed and synthesized.
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  52 showed strong Mcl-1 binding affinity over other Bcl-2 family members.
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  52 showed potential to overcome Venetoclax resistance.
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  52 activated apoptosis in an Mcl-1-dependent manner with low cardiotoxicity.
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  52 possessed favorable druglike properties and oral bioavailability.

关键词： Co/Zr doping   NaNi1/3Fe1/3Mn1/3O2   High-voltage   Structural stability   Sodium-ion batteries  

摘要：

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  Co/Zr doping enlarges Na-layer spacing to optimize lattice structure.
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  The high-voltage O3 → P3 phase transition is suppressed.
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  Co/Zr-doped NFM cathodes exhibit good high-rate performance and air stability.
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  CoZr-NFM||hard carbon full cells deliver high reversible capacity.

关键词： Manganese(II) complexes   Cytotoxicity   Reactive oxygen species   DNA binding   BSA binding   Molecular docking  

摘要：

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  Ten manganese(II) complexes based on 5-(4-chlorophenyl)-1H-tetrazole and N,N'-chelators were successfully prepared and structurally characterized.
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  Compound 6, based on 1,10-phenanthroline-5,6‑dione, showed the highest cytotoxicity against SK-LU-1 cells (LC₅₀ = 0.5 ± 0.2 μM) with a selectivity index of 48; notable activity was also observed for A549 cells (LC₅₀ = 1.8 ± 0.3 μM, SI = 14).
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  The cytotoxic mechanism involves mitochondria-independent ROS overproduction and inhibition of tumor cell migration.
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  DNA binding, confirmed by spectroscopy and docking, may contribute to their antiproliferative effects.
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  Under reducing conditions, complex 6 retains its structural integrity, whereas complex 9 decomposes with the loss of phendione ligands.

关键词： Coumarin derivative   Schiff base   Metal complexes   Single crystal   Alzheimer’s disease  

摘要：

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  A multifunctional coumarin derivative as AD theranostics candidate was synthesized.
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  1-Cu(Ⅱ)/Mn(Ⅱ) was synthesized and characterized by single crystal X-ray diffraction.
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  1 had strong metal chelation, antioxidant and Aβ aggregation inhibition activities.
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  1 exhibited high sensitivity and selectivity for Al³⁺ with LOD at the nM level.
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  DFT calculations helped the study of diagnostic mechanism of probe 1 on Al³⁺.

关键词： 6061 aluminum alloy   Acidic simulated seawater   Galvanic corrosion   Rare earth modification (La/Ce)  

摘要： The application of aluminum alloys is limited by galvanic corrosion caused by secondary phases. This study demonstrates that the addition of 0.05 wt% LaCe (La:Ce =1:1) to as-cast 6061 alloy transforms needle-like β-AlFeSi into fine granular α-AlFeSi and refines Mg₂Si, thereby minimizing the corrosion rate. Excessive addition (≥0.10 wt%) leads to the clustering of RE-rich phases with high Volta potential, which exacerbates pitting corrosion. In acidic simulated seawater, galvanic corrosion proceeds continuously.

关键词： N-heterocycles   Click reaction   Chitosan   Anti-Alzheimer's   Antidiabetic  

摘要：

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  New quinoline-triazole-isatin hybrids successfully synthesized and fully characterized.
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  Chitosan nano-encapsulation consistently enhances multi-target enzyme inhibition.
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  CNPs 5* shows excellent AChE inhibition; all compounds target MAO-B potently.
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  CNPs 6* surpasses acarbose in α-amylase inhibition.
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  Enzyme kinetics, docking, and DFT collectively rationalize the observed activity.

关键词： Claw-free graph   Coloring   Cubic graph   Graph   Packing chromatic number   S-packing coloring  

摘要： It was recently proved that every claw-free cubic graph admits a $(1,1,2,2)$-packing coloring—that is, its vertex set can be partitioned into two 1-packings and two 2-packings. This result was established by Brešar et al. (2025). In this paper, we provide a simpler and shorter proof.

关键词： Acute lung injury   Sepsis   Ulcerative colitis   IL-6   NF-κB   c-Kit  

摘要：

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  25 novel anti-inflammatory pyridazine derivatives were designed and synthesized.
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  z18 significantly inhibited the release of IL-6 in J774A.1 and RAW264.7 cells.
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  z18 could target on c-Kit and inhibit inflammation by suppressing NF-κB pathway.
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  z18 could significantly alleviate LPS-induced ALI, sepsis and UC.
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  z18 demonstrated a favorable safety profile in the mouse toxicity study.