课程文献中心 更多>>

关键词： Aviation kerosene   Surrogate fuel   Flame structure   Skeletal combustion mechanism   Laminar premixed flame   Molecular-beam mass spectrometry  

摘要： This work presents, for the first time, both experimental and numerical investigations of the thermal and chemical structure of laminar premixed flames of aviation kerosene TS-1 and its four-component surrogate fuel, SU4 (n-decane, isocetane, methylcyclohexane, and tetralin). Experiments were conducted for lean (φ = 0.8) and stoichiometric (φ = 1.0) mixtures at atmospheric pressure. Species mole fraction profiles for more than 20 compounds, including key intermediates and radicals, were measured using soft-ionization molecular-beam mass spectrometry. The flame structures of TS-1 and SU4 show good agreement for most species, confirming the suitability of the surrogate for modeling high-temperature combustion behavior of the real fuel, with the exception of soot formation processes. Based on the experimental data, the detailed kinetic mechanism CRECK_2003_TOT_HT was validated. The main discrepancies were associated with the tetralin sub-mechanism. A reduced skeletal mechanism, KCPsur, consisting of 85 species and 183 reactions, was developed using the Directed Relation Graph (DRG) and Computational Singular Perturbation (CSP) methods. The KCPsur mechanism demonstrates predictive performance comparable to the detailed CRECK mechanism, while reducing computational cost by more than a factor of 32. This makes it suitable for CFD simulations of gas turbine combustion systems, particularly in cases where soot formation is not the primary focus.

关键词： 11F11   11F03   Poincaré series of index 1   Monomial relations of index 1 Poincaré cusp forms  

摘要： It is well known that an Eisenstein series can be written as a product of Eisenstein series only in very few particular cases, for example, $E_8=E_4^2$, $E_{10}=E_4{E}_6$ and $E_{14}=E_4{E}_{10}$. Moreover, it is also known that a Hecke eigenform cannot be written as a product of any other Hecke eigenforms, unless they are forced by the dimension restrictions. Also, it turns out that the equality between two monomials of the Eisenstein series can be reduced to the above-mentioned relations. In this article, we investigate the question of possible equality between two monomials of the Poincaré cusp forms of index 1. R.A. Rankin proved that for any even integer $k\ge 4$, the zeros of the Poincaré cusp form of weig

摘要： This study investigates the role of Fe- and Mn- as a B-site transition metal cation in neodymium-based perovskite Nd_1-xSr_xBO₃ (B = Mn, Fe) for two-step thermochemical splitting of CO₂. Sr substitution (x = 0, 0.2, 0.4, 0.6, 0.8) was employed to tune the redox thermodynamics of Nd–based perovskites in Nd_1-xSr_xBO₃ (B = Mn, Fe). Ferrites (Nd_1-xSr_xFeO₃) exhibited the largest first–cycle O₂ release (92–913 µmol/g) but give low thermal oxidation CO yield (40–60 µmol/g) with only partial recovery in the second cycle. In ferrites, XPS confirmed a reduced, vacancy–rich, carbonate–covered surface after cycling. Manganites show smaller O₂ release yet efficient re–oxidation at mid–Sr with high % re-oxidation yield; their Mn 2p and O 1 s spectra change modestly and return toward the as–calcined state. DFT maps oxygen–vacancy formation energies that are lower for ferrites and higher for manganites at the same Sr- doping level; the ferrite landscape is also smoother, which supports fast vacancy percolation. XRD/Rietveld indicates oxygen–deficient starting references for several ferrites (%Sr = 40, 60, 80) and, together with the yields, points to a partial perovskite-brownmillerite excursion that is not fully reversed in CO₂. The results identify a mechanism split: Fe–based compositions are anion–centered and prone to deep but only partly reversible reduction; Mn–based compositions are cation–centered and deliver balanced depth and reversibility.

关键词： Anaerobic fermentation   Glycerin   H2   Flux balance analysis  

摘要：

• •
  Higher H₂ ratios enhanced 1,3-PDO production to mitigate NADH stress.
• •
  Elevated headspace H₂ shifted fermentation from ethanol-to butyric-type.
• •
  FBA quantified a 72% increase in homoacetogenesis flux at 75% H₂.

关键词： Hashimoto thyroiditis   Omentin-1   HMGB1   Autoimmune thyroid disease   Adipokines   Inflammation  

摘要：

• •
  Hashimoto thyroiditis patients had lower circulating omentin-1 and HMGB1 levels than healthy controls.
• •
  Group differences in omentin-1 and HMGB1 persisted after adjustment for age, sex, and insulin levels.
• •
  Free T3 and free T4 were similar between groups, whereas TSH and thyroid hormone ratios differed.
• •
  Biomarker–clinical associations were more evident in controls, suggesting altered regulatory patterns in Hashimoto thyroiditis.
• •
  HMGB1 demonstrated excellent diagnostic accuracy (AUC = 0.802) and omentin-1 good diagnostic accuracy (AUC = 0.724) for the identification of Hashimoto thyroiditis.

关键词： Exponential sums   Prime numbers   Uniform distribution modulo 1   Sum of digits function  

摘要： We study sets N of the prime numbers defined by combinations of arithmetic constraints. For a fixed real number alpha, we investigate the uniform distribution modulo one of the sequence (alpha p)(p is an element of N). (c) 2026 Published by Elsevier Inc.

关键词： IVX-121   respiratory syncytial virus   RSV   vaccine   virus-like particle  

摘要： Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in all age groups, with substantial burden in older adults. Here, we report the safety and immunogenicity of IVX-121, an investigational virus-like particle vaccine against RSV. This Phase 1/1b trial (EudraCT number: 2020-003633-38) randomized 90 healthy young (18-45 y of age;Phase 1) and 130 older adults (60-75 y of age;Phase 1b) to receive a single intramuscular injection of IVX-121 at low (25 & micro;g medium (75 & micro;g or high (250 & micro;g) dose, with/without the adjuvant aluminum hydroxide (Al[OH]3 or placebo. Outcomes were assessed through Day 180. Older adult participants who had received IVX-121 or placebo could continue into an extension study in which safety was assessed for an additional 6 months before receiving IVX-121 (75 & micro;g, unadjuvanted, open-label) on Day 365;safety and immunogenicity were assessed up to Day 546. Adverse reactions were generally mild, and there were no vaccine-related serious adverse events. All IVX-121 dose levels and formulations boosted preexisting RSV neutralizing antibody (nAb) responses. Although not statistically powered to compare treatment groups, there was no clear dose response and the adjuvant Al(OH)3 did not appear to improve immunogenicity. For both age groups, IVX-121 induced nAbs against RSV A and B, which remained above baseline levels for at least 6 months. A second dose of IVX-121 in older adults elicited a modest increase in nAbs against RSV A but not RSV B. Overall, IVX-121 had a favorable safety profile and induced immune responses against RSV in young and older adults.

关键词： Renal cell carcinoma   therapeutic vaccination   VEGFR inhibition   PD-1 blockade   tumor microenvironment   T-cell immunity  

摘要： Despite significant progress achieved by combining VEGFR tyrosine-kinase inhibitors (TKIs) with immune checkpoint inhibitors (ICIs complete responses remain rare in metastatic renal cell carcinoma (mRCC highlighting the need for strategies that optimize therapeutic synergy. Here, we show that the efficacy of VEGFR blockade, vaccination, and PD-1 inhibition critically depends on treatment sequence. Using an orthotopic RENCA model, we show that short-term VEGFR inhibition with axitinib transiently remodels tumor vasculature, alleviates hypoxia, and limits suppressive myeloid subsets, thereby generating an immune-permissive window. Administering a survivin-based long-peptide vaccine (SVX) during this preconditioning phase elicits strong Th1-polarized CD4(+) and cytotoxic CD8(+) T-cell infiltration, which exhibit a polyfunctional cytokine and chemokine profile. When PD-1 blockade is introduced concomitantly with vaccination, after, rather than during, axitinib treatment, the triple regimen (axitinib + [SVX + anti-PD-1 achieves durable tumor control with a high rate of complete responses, outperforming all other treatment schedules. Mechanistically, this sequence aligns vascular reprogramming, antigen-specific priming, and checkpoint release, converting an immune-excluded tumor into a T-cell-dominated, cytotoxic niche. Collectively, these findings identify temporal coordination as a critical determinant of therapeutic success and establish a mechanistically grounded framework for integrating vascular preconditionning, tumor-antigen vaccination, and PD-1 blockade as a curative immunotherapy strategy in renal carcinoma.

关键词： Synthetic Aperture Radar (SAR)   flood mapping   Google Earth Engine (GEE)   Multilayer Perceptron (MLP)   Deep Learning   graphical user interface (GUI)  

摘要： Rapid and accurate flood mapping and monitoring are essential for effective disaster management, response, and recovery, as well as for advancing hydrological sciences. Despite the increasing availability of geospatial data and cloud platforms like Google Earth Engine (GEE existing GEE-based flood mapping applications largely depend on traditional thresholding techniques requiring manual input or struggle with latency due to loose-coupling of complex models. This study introduces DeepSAR Flood Mapper, a novel, fully automated deep learning-based flood mapping application on the GEE cloud platform as an operational, publicly accessible tool, providing interactive and near-real-time capabilities globally. DeepSAR Flood Mapper utilizes a pre-trained Multilayer Perceptron (MLP) deep learning model, selected for its computational efficiency and ability to model highly nonlinear functions, facilitating seamless integration with GEE. The model integrates two crucial input datasets: Sentinel-1 Synthetic Aperture Radar imagery (VV and VH polarization) for all-weather surface water detection, and Height Above the Nearest Drainage topographic data to mitigate commission errors in elevated areas and enhance reliability. Trained on a combination of global benchmark datasets and historical flood maps, the MLP model is deployed using an Offline Training and Online Prediction coupling strategy, which eliminates data transfer bottlenecks and allows for seamless, on-demand prediction within GEE. The application features an intuitive user interface that allows users to define an Area of Interest and target date, requiring no specialized knowledge. Performance evaluation demonstrates that DeepSAR Flood Mapper significantly improves flood mapping accuracy compared to traditional approaches, including Otsu's thresholding and classical machine learning models, Support Vector Machines and Random Forests. Its near-real-time capability supports timely and scalable flood monitoring across div