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关键词： Grassmann embedding   Intriguing set   Symplectic (dual) polar space   Symplectic group   Third exterior power   Tight set  

摘要： We present an infinite family of $(q^3+1)$–tight sets of the symplectic polar space $\mathcal{W}(13,q)$, q odd, admitting the symplectic group $\mathrm{PSp}(6,q)$ as an automorphism group. Our construction relies on the geometry of the dual polar space $D\mathcal{W}(5,q)$.

关键词： Dual-modality MRI/PAI imaging   Liver fibrosis   MnO(2) nanozyme   Oxidative stress   TGF-β1/Smad pathway  

摘要： Liver fibrosis, characterized primarily by oxidative stress and excessive extracellular matrix deposition, represents a significant health burden. TGF-β1/Smad pathway activation serves as a central driver of this process. Unfortunately, current clinical treatments for liver fibrosis all have certain limitations, highlighting the urgency of developing novel therapeutic approaches. In this study, Ganoderma lucidum polysaccharide (GLP)-MnO₂ nanoenzymes primarily treat liver fibrosis through two mechanisms: first, it exhibits potent activity of antioxidant enzymes, such as catalase (CAT) and superoxide dismutase (SOD), successfully scavenging superoxide anion (·O₂⁻), hydrogen peroxide (H₂O₂), and hydroxyl radicals (·OH) in fibrotic liver regions to alleviate oxidative stress. Second, it prevents the TGF-β1/Smad pathway from being activated. Consequently, fewer Collagen I, α-SMA, and inflammatory mediators TNF-α, IL-6, and IL-1β are produced. Additionally, this nanozyme exhibits passive liver targeting and dual-modality photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) properties, providing crucial support for both therapeutic intervention and disease assessment in liver fibrosis. Collectively, these results show the therapeutic potential of GLP-MnO₂ nanozyme in treating liver fibrosis.

关键词： Alzheimer’s disease   soluble Aβoligomers   glutamate transporter 1   ceftriaxone   hippocampal synaptic plasticity   long-term potentiation   mitochondria   presynaptic  

摘要： In Alzheimer’s disease,perturbations of glutamate neurotransmission lead to synaptic dysfunction and synapse *** studies have used glutamate transport inhibitors to demonstrate that soluble oligomers of amyloid-β induce synaptic dysfunction by interrupting glutamate uptake mediated by glutamate transporter 1,the major glutamate transporter in the *** cellular targets of the synaptic effects of soluble amyloid-β oligomers,including the nature of any interaction with glutamate transporter 1,remain *** have generated a conditional glutamate transporter 1 knockout mouse to investigate cell-type specific functions of glutamate transporter *** excitatory postsynaptic potentials were examined in the CA1 region of mouse hippocampal *** confirmed that hippocampal long-term potentiation impairment is induced by both soluble Aβ oligomers and glutamate uptake ***-β oligomers,including those isolated directly from the cortex of patients with Alzheimer’s disease,failed to inhibit hippocampal long-term potentiation in neuronal glutamate transporter 1 but not astrocytic glutamate transporter 1 knockout *** masking or occlusion of the effect of soluble Aβ oligomers by knockout of glutamate transporter 1 in neurons suggests that the metabolic or signaling consequences of knockout of glutamate transporter 1 in neurons and oAβ inhibition of synaptic plasticity show epistasis and thus share a similar molecular *** extend these observations,we tested the effects of other types of manipulation of glutamate homeostasis on synaptic plasticity and the pathophysiology of soluble Aβ ***,which upregulates glutamate transporter 1 levels,among other effects,prevented the impairment of long-term potentiation by soluble Aβ ***,our findings suggest that the effects of amyloid-β on synaptic function are highly dependent on glutamate reuptake homeostasis and that the disruption of synaptic function by s

关键词： Semiconductor   Bandgap tuning   Optoelectronic properties   Optical anisotropy   Chalcogenide perovskites  

摘要： This work presents a comparative study on the structural modification and tuning of the optical properties of wide band gap sulfides belonging to the ${\mathrm{AHfS}}_3$ family, ${\mathrm{CaHfS}}_3$ and ${\mathrm{SrHfS}}_3$. The energy band gap of ${\mathrm{AHfS}}_3$(A=Ca, Sr) is tuned by substituting Hf with Ti at varying concentrations. Our calculations reveal that increasing Ti content essentially decreases the energy band gap from 2.248 eV to 1.097 eV in ${\mathrm{CaHf}}_{1-\mathrm{x}}{\mathrm{Ti}}_{\mathrm{x}}{\mathrm{S}}_3$ and from 2.183 eV to 1.138 eV in